摘要
目的:探讨小窝蛋白-1(caveolin-1,CAV1)及雌激素受体α(estrogen receptor alpha,ERα)在卵巢癌组织中的表达情况,并分析其与患者临床病理特征和预后的关系。方法:免疫组织化学方法检测卵巢癌、卵巢交界性肿瘤、卵巢良性肿瘤及正常卵巢组织中CAV1蛋白及ERα的表达,分析其与卵巢癌临床病理参数间的关系及对预后的影响。结果:CAV1在卵巢癌组织中表达明显下调(P=0.001),且其在卵巢癌组织中的表达率与组织学分级、FIGO分期、病理类型、腹水细胞学、大网膜转移及淋巴结转移显著相关(P<0.05);但CAV1表达率与ERα表达率之间未见相关性(P>0.05)。Kaplan-Meier生存分析显示,CAV1表达阴性者的预后较差(P<0.001)。COX比例风险模型多因素分析显示,组织学分级及是否伴有大网膜转移是影响卵巢癌预后的独立因素(P<0.05)。结论:CAV1蛋白表达缺失可能与生存率有关,CAV1表达阴性的卵巢癌患者可能预后不良。
Objective:To explore the caveolin-1(CAV1) and estrogen receptor alpha(ERα) expression in ovarian carcinoma tissues,and to evaluate their correlation with the clinical pathological features and the prognosis of the patients.Methods:Immunohistochemistry(IHC) analysis was performed to examine the expression of CAV-1 and ERα in ovarian carcinoma,borderline ovarian tumor,benign ovarian tumor,and normal ovarian tissues.The correlation between CAV1 expression and clinico-pathological parameters was analyzed.Results:The expression of CAV1 was significantly down-regulated in ovarian carcinoma(P=0.001).The expression level of CAV1 had significant correlation with the histological grade,FIGO surgical stage,pathology types,ascitic cytology,omentum majus metastasis,and lymph node metastasis in ovarian carcinoma(P<0.05).However,the expression of CAV1 was not correlated with ERα expression(P>0.05).Kaplan-Meier survival analysis showed that CAV1-negative patients had poor prognosis(P<0.001).A multivariate analysis based on the COX proportional hazard model demonstrated that histological grade and omentum majus metastasis were the independent prognostic factors of ovarian carcinoma(P<0.05).Conclusion:The absence of CAV1 expression was closely associated with survival rate of the patients.The ovarian cancer patients with negative CAV1 expression might have poor prognosis.
出处
《肿瘤》
CAS
CSCD
北大核心
2010年第11期950-954,共5页
Tumor
关键词
卵巢肿瘤
窖蛋白1
雌激素受体Α
预后
Ovarian neoplasms
Caveolin-1
Estrogen receptor alpha
Prognosis
