摘要
目的研究甘珀酸钠苦参素包合物(OCSIC)抗胃溃疡和镇痛的作用。方法采用小鼠束缚水浸应激性胃溃疡模型,观察OCSIC的抗溃疡作用;采用小鼠醋酸扭体模型、热板致痛模型,观察OCSIC的镇痛作用。结果 200、100 mg.kg-1甘珀酸钠苦参素1:1的包合物(OCSIC-1)及150 mg.kg-12:1的包合物(OCSIC-2)可抑制小鼠束缚水浸应激性胃溃疡;OCSIC-1和OCSIC-2呈剂量依赖性抑制醋酸导致的小鼠扭体反应,延长小鼠舔后足的潜伏期,提高小鼠的痛阈。结论 OCSIC对小鼠束缚水浸应激性胃溃疡有保护作用;有较强的镇痛作用。
OBJECTIVE To study the anti-gastric ulcer and analgesic effects of oxymatrine-carbenoxolone sodium inclusion complex.METHODS The anti-gastric ulcer after administration of oxymatrine-carbenoxolone sodium inclusion complex was observed in the models of gastric ulcer induced by restraint-water stress in mice.Acetic acid writhing and hot plate method in mice wereadopted.The numbers of writhing and the latencies of paw licking after intraperitoneal injection of different doses of oxymatrine-carbenoxolone sodium...
出处
《华西药学杂志》
CAS
CSCD
北大核心
2010年第6期697-699,共3页
West China Journal of Pharmaceutical Sciences
基金
宁夏卫生厅科研项目(宁卫2008034)
宁夏医科大学面上项目(XM200703)
关键词
甘珀酸钠苦参素包合物
胃溃疡
镇痛
Oxymatrine-carbenoxolone sodium inclusion complex
Gastric ulcer
Analgesic action
