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紫杉醇脂质体联合卡铂与传统紫杉醇联合卡铂治疗晚期卵巢癌的疗效及毒副作用比较 被引量:12

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摘要 目的比较紫杉醇脂质体+卡铂与传统紫杉醇+卡铂治疗晚期卵巢癌的疗效和毒性。方法 56例初治晚期卵巢癌患者随机分为紫杉醇脂质体+卡铂组(A组)28例和传统紫杉醇+卡铂组(B组)28例,化疗6~8周期后评价临床缓解率和药物毒性。结果 A组有效率为75.0%,B组有效率71.4%,两组疗效差异无显著性(P>0.05)。胃肠道反应、皮疹、面部潮红、呼吸困难和肌肉关节疼痛的发生率A组较B组低(P<0.05)。结论紫杉醇脂质体+卡铂治疗晚期卵巢癌有效率不低于传统紫杉醇+卡铂,但毒性反应明显减轻,地塞米松用量明显减少。
作者 郑亚峰
出处 《柳州医学》 2010年第3期63-65,共3页
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