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胰腺癌患者血清中CA19-9、CA50、CA242、CEA的水平变化及意义 被引量:4

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摘要 目的探讨胰腺癌患者血清肿瘤标志物血清糖类抗原(CA)19-9、CA50、CA242、癌胚抗原(CEA)水平,及其与胰腺癌术前诊断、临床分期、肿瘤大小以及预后的关系。方法分别测定38例胰腺癌(观察组)和25例胰腺良性病变(对照组)患者血清中CA19-9、CA50、CA242和CEA。探讨其与胰腺癌临床分期、肿瘤大小及预后的关系。结果观察组血清CA19-9、CA50、CA242和CEA水平明显高与于对照组,术后血清CA19-9、CA50、CA242和CEA水平较术前明显下降,TS3+TS4、Ⅲ+Ⅳ期患者血清CA19-9、CA50、CA242和CEA水平分别高于TS1+TS2、Ⅰ+Ⅱ期者(P均<0.05)。结论胰腺癌患者血清CA19-9、CA50、CA242和CEA水平对胰腺癌患者术前诊断、临床分期和肿瘤大小的判断有一定的参考意义。
出处 《山东医药》 CAS 北大核心 2010年第50期50-51,共2页 Shandong Medical Journal
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  • 1尚志芳,朱玉群,杨昭徐.四项肿瘤标志物联合检测对胰腺癌的诊断价值[J].疾病监测,1996,11(11):408-411. 被引量:5
  • 2张韶光,张先富.胰腺癌肿瘤标志物的临床应用进展[J].中国医药导报,2007,4(06Z):9-11. 被引量:11
  • 3Rydlander I, Ziegler E, Bergman T, et al. Molecular characterization of a tissuepolypeptide-specific-antigen epitope and its relationship to human cytokeratin 18 [J]. Eur J Biochem, 1996,241 (2) : 309-314.
  • 4Lamer R. Role of tumor markers cytogenetics [ J]. Am Oncol, 1999,10 ( suppl 4 ) : 145-149.
  • 5Barbra S, Antonina HS, Witold K, et al. Tissue polypeptide specific antigen(TPS), a marker for differentiation between pancreatic carcinoma and chronic pancreatitis [J]. Cancer, 2000,89( 1 ) :83-88.
  • 6Jalanko H, Kuusela P, Roberts P, et al. Comparision of a new tumour marker, CA 19-9, with alpha-fetoprotein and carcinoembryonic antigen in patients with upper gastrointestinal diseases [ J]. J Clin Pathol, 1984, 37(2) : 218-222.
  • 7Eskelinen M, Haglund U. Developments in serologic detection of human pancreatic adenocarcinoma [ J]. Scand J Gastroenterol, 1999, 34 (9) : 833-844.
  • 8Cappelh G, Paladini S, D'Agata A. Tumor markers in the diagnosis of pancreatic cancer [J]. Tumori, 1999, 85(1 Suppl 1): s19-21.
  • 9Ni XG, Bai XF, Mao Y, et al. The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancer [J]. EurJ Surg Oncol, 2005, 31(2): 164-169.
  • 10Takahashi Y, Takeuchi T, Sakamoto J, et al. The usefulness of CEA and/or CA 19-9 in monitoring for recurrence in gastric cancer patients: a prospective clinical study [ J ]. Gastric Cancer, 2003, 6 (3) : 142-145.

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  • 1Mancuso A,Calabro F,Sternberg CN.Current therapies and ad-vances in the treatment of pancreatic cancer[J].Crit Rev OncolHematol,2006,58(3):231-241.
  • 2Friedrichs K,Gluba S,Eidtmann H,et al.Overexpression of p53and prognosis in breast cancer[J].Cancer,1993,72(12):3641-3647.
  • 3Jemal A,Sicgel R,Ward E,et al.Cancer statistics,2009[J].CACancer J Clin,2009,59(4):225-249.
  • 4Baeckstrom D,Hansson GC,Nilsson O,et al.Purification andcharacterization of a membrane-bound and a secreted mucin-typeglycoprotein carrying the carcinoma-associated sialyl-Lea epitope ondistinct core proteins[J].J Biol Chem,1991,266(32):21537.
  • 5Kuusela P,Haglund C,Roberts PJ.Comparison of a new tumourmarker CA 242 with CA 19-9,CA 50 and carcinoembryonic antigen(CEA)in digestive tract diseases[J].Br J Cancer,1991,63(4):636.
  • 6Ni XG,Bai XF,Mao YL,et al.The clinical value of serum CEA,CA19-9,and CA242 in the diagnosis and prognosis of pancreaticcancer[J].Eur J Surg Oncol,2005,31(2):164-169.
  • 7庄珊珊,陈炯玉,方裕森,等.血清CAl99与CEA检测对结直肠癌的诊断价值[J].现代肿瘤学,2010,18(7):1395-1396.
  • 8Zhao P, Dai M, Chen W, et al. Cancer trends in China [ J ]. Jpn J Clin Oncol, 2010,40(4) :281-285. DOI: 10. 1093/jjco/hyp187.
  • 9Jemal A, Bray F, Center MM, et al. Global cancer statistics [ J ]. CA Cancer J Clin,2011,61 (2) :69. DOI : 10. 3322/caac. 20107.
  • 10邱毅,陈炼,曾彤琴,刘毅菊.联合检测血清胃癌肿瘤标志物的临床应用[J].浙江临床医学,2008,10(3):412-413. 被引量:15

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