摘要
对39例有明确围产期缺氧史的新生儿(重度窒息12例,HIE27例)的预后及影响因素进行了分析。35例存活小儿分别在其3,6,9,12个月进行了Gesell法智能发育水平测定。预后良好及基本正常占82.05％,预后不良17.95％。经多元逐步回归分析,孕周、出生体重、脑水肿、颅内出血严重程度与预后关系密切.进一步进行单因素分析发现,孕周<34周,出生体重<1500g,脑水肿持续4天以上,颅内出血Ⅲ～Ⅳ°时对预后威胁最大,可作为疾病早期估价预后的参考.对脑损伤小儿进行早期干预,有助于挖掘发育潜力,在原有基础上改善预后。
This study analyzed the prognosis and its influencing factors in 39 cases of neonates with a confirmed history of perinatal hypoxia(12 cases of severe asphyxia and 27 cases of HIE). Gesell intelligent and development test was administered to the 35 infants who survived on the 3rd, 6th, 9th, and 12th month. Infants with good or normal outcomes accounted for 82. 05%, while 17. 95% showed unfavorably prognosis. Step wise multiple regression analysis reveals that the prognosis is closely related to the gestational age, birth weight, and severity of cerebral edema and intracranial hemorrhage. Chi-square test of individual factors shows that gestational age under 34 weeks, birth weight below 1500g, cerebral edema over 4 days and intracranial hemorrhage Ⅲ ~ Ⅳ degree are high risk factors for bad outcomes. These factors can be used in early prediction of prognosis. This study also suggests that early intervention of infants with perinatal brain damage will help them to develop their potentials,and improve the prognosis.
