期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

hPOT1在端粒长度维持机制中的研究进展 被引量：1

下载PDF
导出
摘要 端粒是真核生物染色体末端的重要结构复合物,对维持染色体稳定性起着重要作用。端粒长度的调控非常复杂。端粒长度的维持,一方面依赖端粒酶,另一方面则依赖端粒结合蛋白。端粒保护蛋白(POT1)为端粒单链结合蛋白,近年来对hPOT1结构、功能及其在肿瘤中的表达研究表明,其与端粒长度的维持密切相关。
作者 杜小玲 孙宏声 张维铭
机构地区 天津医科大学实验中心分子生物学实验室
出处 《国外医学（临床生物化学与检验学分册）》 2005年第8期520-522,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 hPOTl 端粒长度 维持机制 端粒保护蛋白 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献17

  • 1Miura T, Mattson MP, Rao MS. Cellular lifespan and senescence signaling in embryonic stem cells. Aging Cell,2004, 3(6):333-343.
  • 2Maser RS, DePinho RA. Connecting chromosomes, crisis, and cancer. Science, 2002, 297(5581): 565-569.
  • 3Smogorzewska A, de-Lange T. Regulation of telomerase by telomeric proteins. Annu Rev Biochem, 2004, 73: 177-208.
  • 4Baumann P, Podell E, Cech TR. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol Cell Biol, 2002, 22(22): 8079-8087.
  • 5Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science, 2001, 292(5519): 1171-1175.
  • 6Loayza D, De-Lange T. POT1 as a terminal transducer of TRF1 telomere length control. Nature, 2003, 423(6943): 1013-1018.
  • 7Liu D, Safari A, O′Connor MS, et al. PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol, 2004, 6(7): 673-680.
  • 8Mitton-Fry RM, Anderson EM, Hughes TR, et al. Conserved structure for single-stranded telomeric DNA recognition. Science, 2002, 296(5565): 145-147.
  • 9Colgin LM, Baran K, Baumann P, et al. Human POT1 facilitates telomere elongation by telomerase. Curr Biol, 2003, 13(11): 942-946.
  • 10Blackburn EH. Switching and signaling at the telomere. Cell, 2001, 106(6): 661-673.

二级参考文献5

  • 1Blasco MA, Gasser SM, Lingner J. Telomeres and telomerase[J].Genes Dev, 1999,13:2353
  • 2Baumann P, Cech TR. Pot1,the putative telomere end-binding protein in fission yeast and humans[J]. Science,2001,292(5519):1171
  • 3Stewart SA, Porath I, Carey V J, et al. Erosion of the telomeric single-strand overhang at replicative senescence[J]. Nature Genetics, 2003,33:492
  • 4Colgin LM, Baran K, Baumann P, et al. Human POT1 facilitates telomere elongation by telomerase[J]. Curr Biol, 2003,13(11):942
  • 5De Lange T. Pot1 as a terminal transducer of TRF1 telomere length control[J]. Nature, 2003,424(6943): 1013

同被引文献12

  • 1帖君,房殿春,宁晓燕,罗元辉.人端粒保护蛋白在胃癌中的异常表达及其临床意义[J].胃肠病学和肝病学杂志,2006,15(1):12-14. 被引量：2
  • 2安红梅,胡兵,史云峰,许丽雯,胡云皓,顾耘.补肾填精复方含药血清对WI38细胞衰老的影响[J].陕西中医学院学报,2007,30(1):40-42. 被引量：12
  • 3张之南,沈悌.血液病诊断及疗效标准[M].3版,北京,北京科学出版社,2008:232-235.
  • 4Brummendorf TH,Macie Jewski JP,Mak J,et al. Telomere length in leukocyte subpopulations of patients with aplastic anemia[J]. Blood,2001,97(4):895-900.
  • 5Young NS,Bacigalupo A,Marsh JC. Aplastic anemia: pathophysiology and treatment[J]. Biol Blood Marrow Transplant,2010,16(1):S119-125.
  • 6Baumann P,Cech TR. Pot1,the putative telomere end-binding protein in fission yeast and humans[J]. Science,2001,292(5519):1171-1175.
  • 7Young NS. Telomere biology and telomere diseases:implications for practice and research[J]. Hematology Am Soc Hematol Educ Program,2010(1):30-35.
  • 8Scheinberg P,Cooper JN,Sloand EM,et al. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse,malignant transformation,and survival in severe aplastic anemia[J]. JAMA,2010,304:1358-1364.
  • 9De Lange T. T-loops and the origin of telomeres[J]. Nat Rev Mol Cell Biol,2004,5(4):323.
  • 10Colgin LM,Baran K,Baumann P,et al. Human POT1 facilitates telomere elongation by telomerase[J]. Curr Biol,2003,13:942- 946.

引证文献1

二级引证文献2

国外医学（临床生物化学与检验学分册）
2005年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部