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聚酮类化合物生物合成的代谢工程研究进展 被引量：6

The Application of Metabolic Engineering in Polyketide Biosynthesis
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摘要 聚酮化合物是一类重要的具有生物活性的次级代谢物。本文讨论了以聚酮生物合成酶为核心的聚酮化合物生物合成途径,以及近年来有关代谢工程在聚酮类化合物生物合成方面的研究工作进展,主要包括将聚酮生物合成途径引入新的宿主、代谢流量分析在提高聚酮化合物中的应用及合成新的聚酮化合物等。 Polyketides are an extremely important class of bioactive secondary metabolites. Considerable efforts have been directed towards improved production processes and the generation of novel polyketide structures for use as antibiotics. Metabolic engineering of polyketide-producing is a primary focus of these efforts,
作者 王虹 张惟材 汪建华
机构地区 军事医学科学院生物工程研究所
出处 《生物技术通讯》 CAS 2005年第4期448-451,共4页 Letters in Biotechnology
关键词 聚酮化合物 代谢工程 metabolic engineering polyketide
分类号 Q81 [生物学—生物工程]
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参考文献19

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二级参考文献79

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共引文献32

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引证文献6

二级引证文献14

生物技术通讯
2005年 第4期

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