摘要
[目的]观察膳食补充不同剂量锌对老龄大鼠T淋巴细胞和自然杀伤(NK)细胞活性的影响。[方法]通过喂饲锌含量不同的饲料,构建老龄期大鼠补锌模型;6w后测定血清锌、脾脏T淋巴细胞转化率和NK细胞活性。[结果]实验组老龄大鼠脾脏T淋巴细胞转化率、NK细胞活性和血清锌含量明显高于正常组(P<0．05)。NK细胞活性随着血清锌含量的增加活性增强并呈正相关(r=0．764,P<0．01)。[结论]膳食补锌一定程度上可以延缓老龄引起的细胞免疫功能下降。
[Objective] To study the effect of supplement different levels of zinc on the T lymphocyte and NK cell activity in aged rats. [Methods] By raising different levels of zinc of feedstuff to aged rats to estabhsh the supplement zinc model and five weeks later serum zinc and T lymphocyte transformation rate and NK cell activity in spleen were determined. [ Results] T lymphocyte transformation rate, N K cell activity and serum zinc of supplemented groups significantly higher than that in normal group （ P〈 0.05）, NK cell activity had the positive correlation with the serum zinc （ r = 0.764, P 〈 0.01）. [Conclusion] Supplement zinc by feeding can stay cell immunity function that age cause descend.
出处
《武警医学院学报》
CAS
2005年第5期340-342,共3页
Acta Academiae Medicinae CPAPF
