摘要
目的探讨2型糖尿病患者超敏C反应蛋白(hs-CRP)的变化及微量白蛋白尿(MAU)与hs-CRP的关系。方法对160例2型糖尿病患者根据尿白蛋白排泄率(UAER)分为正常白蛋白尿组、微量白蛋白尿组,分别进行空腹血糖和hs-CRP测定,并与100例正常对照组比较。结果2型糖尿病患者hs-CRP明显高于正常对照组(P<0.01),而微量白蛋白尿组hs-CRP值明显高于正常白蛋白尿组(P<0.05)。结论hs-CRP与糖尿病及其血管并发症有关。微量白蛋白尿是心血管病的预测指标,慢性炎症可能起媒介作用。
Objective To explore the changes of high sensitive C - reactive protein （ hs - CRP） level in type 2 diabetes serum and its correlation with microalbuminuria （ MAU）. Methods 160 patients with type 2 diabetes mellitus were divided into 2 groups according to urine albumin excretion rate （ UAEA）, normal albuminutia group and microalbuminuria group. Fasting plasma glucose （FPG） and hs - CRP were detected in all patients and were compared with those obtained from 100 healthy individuals. Result hs - CRP in type 2 diabetes was significantly higher than that of healthy individuals （ P 〈0.01）. When two groups of type 2 diabetes were compared, hs - CRP in the microalbuminuria group was significantly higher than that in normal albuminuria group （P 〈 0. 05）. Conclusion Increased level of hs - CRP may correlate with type 2 diabetes and its complications. Microalbuminuria is a risk factor for cardiovascular complication. Chronic inflammation, as indicated by increased level of hs - CRP, may trigger microalbuminuria and cardiovascular complications.
出处
《中国微循环》
北大核心
2005年第4期273-274,共2页
Journal of Chinese Microcirculation
关键词
糖尿病
C-反应蛋白
微量白蛋白尿
Diabetes mellitus
C - reactive protein（CRP）
Microalbuminuria
