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乳腺癌患者ST13、Hsp70、pS2、雌激素受体和孕激素受体表达及其与生存的关系 被引量:7

The expression of ER,PR,pS2,Hsp70 and ST13,and their interaction with survival in breast cancer patients
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摘要 目的研究乳腺癌患者ST13、Hsp70、pS2、雌激素受体(ER)和孕激素受体(PR)表达及其与生存关系。方法选择1993至1994年间有完整随访资料和蜡块的乳腺癌患者45例,以免疫组织化学法检测ER、PR、pS2、Hsp70和ST13在乳腺癌组织中的表达及相关性分析;并进行KaplanMeier生存率分析和COX生存分析。结果(1)本组乳腺癌组织中ER、pS2、PR、ST13和Hsp70表达的阳性率依次分别为77.8%、68.9%、66.7%、64.4%和62.2%。其中ST13分别与ER、PR和pS2三者呈显著正相关性(分别为P<0.01、P<0.05和P<0.05)。而ER与PR也呈非常显著的正相关性(P<0.01)。(2)KaplanMeier生存率曲线及LogRank显著性检验发现,仅ST13和Hsp70阳性者明显提高乳腺癌患者的5年生存率(P<0.05)。COX生存分析也发现ST13和Hsp70阳性提高乳腺癌患者5年生存(P<0.05)。结论(1)ER、PR、pS2、ST13和Hsp70在乳腺癌组织中均高表达,其中ER与PR及ST13与ER、PR和pS2呈非常显著的正相关性。(2)KaplanMeier生存率分析和COX生存分析均提示ST13和Hsp70阳性者明显提高乳腺癌患者的5年生存率(P<0.05)。 Objective To study the expression of ER, PR, pS2, Hsp70 and ST13, and their interaction with survival in breast cancer patients. Methods The expression of ER, PR, pS2, Hsp70 and ST13 was detected in 45 cases of breast cancer during 1993-1994 with follow-up data, and the Kaplan-Meier survival analysis and COX survival ananlysis were done. Results ( 1 ) The positive rates of ER, PR, pS2, Hsp70 and ST13 were 77.8%, 68.9%, 66.7%, 64.4% and 62.2%, respectively in this group. There was a positive correlation among ER, PR, pS2 and ST13, especially between ER and ST13 (P = 0. 000), ER and PR (P = 0. 000). (2) In Kaplan-Meier survival analysis and Log Rank test, only the patients with expression of ST13 and Hsp70 had the higher 5-year survival rate (P〈0.05), and also in the COX survival anardysis model. Conclusion ER, PR, pS2, Hsp70 and ST13 are abundant in breast cancer. There are very close relationship among ER, PR, pS2 and ST13. But Hsp70 is the independent parameter. The expression of ST13 or Hsp70 can significantly increase the 5-year survival in single or multivariate survival analysis.
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2005年第9期1071-1073,共3页 Chinese Journal of Experimental Surgery
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  • 1Ruibal A, Arias JI, Del Rio MC, et al. Histological grade in breast cancer:association with clinical and biological features in a series of 229 patients. Int J Biol Markers, 2001, 16:56-61.
  • 2Gaci Z, Bouin-Pineau MH, Gaci M, et al. Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors. Int J Oncol, 2001, 18:793-800.
  • 3Tamargo F, Vizoso F, Lamelas M. Analysis of the cytosolic content of the pS2 protein in breast cancer. Rev Esp Med Nucl, 2002, 21:28-33.
  • 4Looi LM, Azura WW, Cheah PL, et al. pS2 expression in infiltrating ductal carcinoma of the breast correlates with oestrogen receptor positivity but not with histological grade and lymph node status. Pathology, 2001,33:283-286.
  • 5Surowiak P, Dziegiel P, Zabel M, et al. Analysis of estrogen receptor(ER) and estrogen-dependent pS2 protein expression in ceils of mammary ductal carcinoma. Folia Histochem Cytobiol, 2001, 39 : 141-142.
  • 6Ruibal A, Arias J, Del Rio MC, et al. Infiltrating ductal carcinomas of the breast in women over 60 years of age. Association with higher cellular proliferation and lower PS2, cell surface and cytosolic hyaluronic acid concentrations. Rev Esp Med Nucl, 2001,20:525-529.
  • 7Montgomery DL, Morimoto R1, Gierasch LM. Mutations in the substrate binding domain of the Escherlchia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling. J Mol Biol, 1999, 286:915-932.
  • 8Chen S, Prapapanich V, Rimerman RA, et al. Interactions of p60, a mediator of progesterone receptor assembly, with heat shock proteins Hsp90 and Hsp70. Mol Endocrinol, 1996, 10:682-693.
  • 9Johnson J, Corbisier R, Stensgard B, et al. The involvement of p23,Hsp90, and immunophilins in the assembly of progesterone receptor complexes. J Steroid Biochem Mol Biol, 1996, 56 : 31-37.
  • 10Ciocca DR, Green S, Elledge RM, et al. Heat shock proteins Hsp27 and Hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer( a Southwest Oncology Group Study). Clin Cancer Res, 1998, 4 : 1263-1266.

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