摘要
胚胎干细胞是从胚胎植入前期胚泡内细胞团分离的细胞,可以长久维持对称性自我更新的未分化状态。多种胞内外细胞因子介导的信号途径参与这种状态的调节。现对胚胎干细胞自我更新途径分子机制进行综述,并提出有待进一步阐明的相关问题。
Embryonic stem cells （ES cells） are derived from the inner cell mass （ICM） of mammalian preimplantation blastocyte. They can undergo symmetrically self-renew to consistently maintain the undifferentiated state. Multiple cytokine-mediated signaling pathways participate in regulating such status of ES cells. We reviewed the molecular signaling pathways being critical to the maintenance of self-renewal of ES cells based on the current research results. And furthermore, we addressed some pending results which seem to be essential for the undifferentiated proliferation of ES cells.
出处
《细胞生物学杂志》
CSCD
2005年第4期379-382,共4页
Chinese Journal of Cell Biology
