摘要
目的观察主要类型热休克蛋白(heatshockprotein,HSP)27、70和90在东方田鼠卵巢癌组织中的表达。方法用SP免疫组化法检测8例东方田鼠卵巢癌组织中HSP27、HSP70和HSP90的表达并用正常卵巢组织作对照。结果HSP27、HSP70和HSP90在东方田鼠卵巢癌中表达的阳性率分别为100%、100%和62.5%,在正常卵巢组织中均为阴性。结论HSP27、HSP70在东方田鼠卵巢癌中呈高表达,HSP90呈低表达或不表达。
Objective To investigate the expression of heat shock protein （HSP） 27, 70 and 90 in Microtus fortis ovarian cancer. Methods Eight cases of spontaneous ovarian cancer and normal ovary were examined by histopathology and assessed for the expression of HSP27, HSP70 and HSP90 using immunohistochemical SP technique. Results All the 8 tumors were histopathologically diagnosed as serous cystadenocarcinoma. The positive-staining rates of HSP27, HSP70 and HSP90 in the cancers were 100% , 100% and 62% , respectively, while all were negative in normal ovary tissue. Conclusion The results demonstrate that HSP27 and HSP70 are overexpressed in the spontaneous ovarian cancers of Microtus Fortis, and the expression of HSP90 is lower. It is worthy of further study whether an animal model of ovarian cancer can be established from such tumorbearing Microtus Fortis and to serve experimental studies on ovarian cancers.
出处
《中国比较医学杂志》
CAS
2005年第4期218-220,共3页
Chinese Journal of Comparative Medicine
基金
湖南省实验动物专项基金(04TH4007)
湖南省自然科学基金(03JJY4070)资助。
