摘要
目的研究血红蛋白(Hb)浓度对食管癌放射治疗疗效的影响.方法1996年8月-1997年10月260例经病理学证实的食管癌患者接受后程加速超分割根治性放疗,采用6MV X线放疗,DT 66～68Gy.放疗前测定血红蛋白含量.根据血红蛋白浓度分为4个组(≥110g/L为正常组,95～109g/L为轻度贫血组,75～94g/L为中度贫血组,小于75g/L为重度贫血组).结果所有患者均随访,其中血红蛋白＜95g/L患者的1、3、5年局控率及生存率低于血红蛋白≥95g/L的患者,差异有显著性.结论血红蛋白浓度对食管癌放射治疗预后有显著影响,血红蛋白水平越低,局控率及生存率也越低.
Objective To evaluate the influence of hemoglobin level on the prognosis of the patients with esophageal cancer treated with radiotherapy. Methods From August 1996 to October 1997,260 cases with pathologically confirmed esophageal cancer received late course accelerated hyperfracfionation radiotherapy （ LCAHR）. All patients were irradiated by 6MV external beam with a total dose of 66 - 68 Gy. The peripheral blood hemoglobin concentration for all patients was measured before radiotherapy. These patients were divided into four groups according to the peripheral blood hemoglobin concentration before radiotherapy： normal（ ≥ 110 g/L） group, low anemia（95 - 109 g/L） group, middle anemia（75 - 94 g/L） group, and heavy anemia（ 〈 75 g/L） group. Results All the patients were followed with a follow-up rate of 95.4%. The 1 - , 3 - , 5 - year local control and survival rates were significantly lower in the patients who had hemoglobin 〈 95 g/L than 〉 95 g/L. Conclusions The lower peripheral blood hemoglobin concentration can influence the local control and survival rates of the patients with esophageal cancer treated by radiotherapy.
出处
《河南肿瘤学杂志》
2005年第5期341-342,共2页
Henan Journal of Oncology
关键词
食管肿瘤
血红蛋白
放射治疗
预后
esophageal cancer
hemoglobin
radiotherapy
prognosis
