摘要
目的:了解脑卒中合并肺部感染患者不同病程的体液免疫功能,以及与神经功能恢复的关系。方法:选择2000-01/2005-03汕头大学医学院第一附属医院收治的113例脑卒中患者为观察对象,按有无肺部感染的症状和体征分为肺部感染组60例和对照组53例。所有患者治疗前后均测定神经功能缺损评分,按其治疗后减分率评估其疗效(91%～100%为基本痊愈,≥18%均为有效);同时检测患者血清IgA,IgG,C3,C反应蛋白,白蛋白评估其体液免疫功能。结果:按意向处理分析,113例患者均进入结果分析。①体液免疫功能各指标比较:对照组患者血清IgA,IgG,C3,C反应蛋白,白蛋白水平在病程1,10和20d比较无差异(P>0.05);同时相点,肺部感染组相应各项指标均低于对照组(P<0.01),且病程越长,血清中各指标的水平越低。②脑卒中疗效:肺部感染组基本治愈率和总有效率均低于对照组(18%比38%;68%比94%,P<0.01)。结论:脑卒中合并肺部感染的患者体液免疫功能低下,是导致肺部感染的原因之一,且病程越长,功能越低下,并且能影响脑卒中患者神经功能恢复。
AIM： To understand the humoral immunological function in patients with pulmonary infection induced by stroke in different progress, and the relationship with neural functional restoration. METHODS： 113 patients with stroke, who treated in the First Affiliated Hospital, Medical College, Shantou University from January 2000 to March 2005, were selected as observation objects. According to the symptom and physical sign with or without pulmonary infection, they were divided into pulmonary infection group with 60 cases and control group with 53 cases. The patients were all tested with the neural functional impairment score before and after treatment. The effect was evaluated by the reduced points rate after treatment （91%-100% for basic cure,≥18% for effective）. Meanwhile, the serum IgA, IgG, C3, C respondcnce protein was detected, and the humoral immunological function was assessed by albumin. RESULTS： According to intention-to-treat analysis, 113 patients were all involved in the result analysis. ① Comparison of humoral immunological function in every index： The serum IgA, IgG, C3, C respondence protein and albumin level in the control group had insignificant difference in the progress of 1, 10 and 20 days （P 〉 0.05）. At the same phase, the corresponding every index in the pulmonary infection was all lower than that in the control group （P 〈 0.01 ）, and the longer the progress, the lower the level of every index in serum was. ② Effect of stroke： The basic healing rate and general efficiency in the pulmonary infection group were lower than that in the control group （18% vs 38%;68% vs 94%, P〈 0.01 ）. CONCLUSION： The humoral immunological function of the patients with pulmonary infection due to stroke is low, which is one of the cause of inducing the pulmonary infection, and the longer the progress, the lower the function was, besides, it has effects on the recovery of neural function in the patients with stroke.
出处
《中国临床康复》
CAS
CSCD
北大核心
2005年第29期12-13,共2页
Chinese Journal of Clinical Rehabilitation
