基因重组人红细胞生成素治疗非肾性贫血15例
摘要
用基因重组人红细胞生成素(rhEpo)治疗非肾性贫血15例,有效10例。对治疗有效组和无效组治疗前后血清铁蛋白水平进行检测,发现有效组在治疗后铁蛋白水平明显下降,提示Fe^(2+)利用得到改善。对治疗后各种不同反应情况做了简要分析。rhEpo是治疗非肾性贫血的有应用前景的造血因子。
出处
《陕西医学杂志》
CAS
1996年第2期85-87,共3页
Shaanxi Medical Journal
二级参考文献17
-
1Youssoufian H,Longmore G,Neumann D,et al.Structure, function, and activation of the erythropoietin receptor. Blood . 1993
-
2Mason-Garcia M,Weill CL,Beckman BS.Rapid activation by erythropoietin of protein kinase C in nuclei of erythroid progenitor cells. Biochemical and Biophysical Research Communications . 1990
-
3Costa-Giomi P,Caro J,Weinmann R.Enhancement by hypoxia of human erythropoietin gene transcription in vitro. Journal of Biological Chemistry . 1990
-
4Imai N,Higuchi M,Kawamura A et al.Physicochemical and biological characterization of asialoerythropoietin.Suppressive effects of sialic acid in the expression of biological activity of human erythropoietin ih vitro. European Journal of Biochemistry . 1990
-
5Barber DL,D’Andrea AD.The erythropoietin receptor and the molecular basis of signal transduction. Seminars in Hematology . 1992
-
6Beru N,Smith D,Goldwasser E.Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein. Journal of Biological Chemistry . 1990
-
7Koury ST,Bondurant MC,Koury MJ et al.Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood . 1991
-
8Fandrey J,Seydel FP,Siegers CP et al.Role of cytochrome P450 in the control of the production of erythropoietin. Life Sciences . 1990
-
9Yelamarty RV,Miller BA,Scaduto RC et al.Three-dimensional intracellular calcium gradients in single human burst-forming units-erythroid-derived erythroblasts induced by erythropoietin. The Journal of Clinical Investigation . 1990
-
10Blanchard KL,Acquaviva AM,Galson DL et al.Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Molecular and Cellular Biology . 1992
-
1李志强.重组人红细胞生成素对非肾性贫血16例治疗观察[J].上海医学,1995,18(5):298-299.
-
2魏建平,施红,李蓉生,李琦,赵声明,范芸,顾惜春.基因重组人红细胞生成素治疗29例非肾性贫血[J].中国新药杂志,1999,8(5):330-332. 被引量:1
-
3柳波.促红细胞生成素治疗非肾性贫血的临床分析[J].中国医药指南,2011,9(27):47-48.
-
4李蓉生,张之南.基因重组人红细胞生成素治疗非肾性贫血[J].中华血液学杂志,1993,14(5):229-231. 被引量:9
-
5杨继芳.促红细胞生成素治疗非肾性贫血的临床应用[J].吉林医学,2005,26(5):549-550.
-
6徐志强,王骏,王鸣和.胱抑素C与冠心病相关性的研究进展[J].心血管病学进展,2008,29(1):64-67. 被引量:36
-
7舒瑛,唐家荣.胱抑素C与心血管疾病的关系[J].心血管病学进展,2010,31(5):673-677. 被引量:13
-
8胡振伟,华银玲,陶雅非,杜朝阳.促红素所致相关性高血压的临床观察[J].中原医刊,2004,31(23):19-20. 被引量:1
-
9谢辉.红细胞生成素治疗肾性贫血的疗效观察[J].中原医刊,2003,30(8):13-13.
-
10金运松,鲍杨漪,夏云玲,夏秀芳,王祖贻,瞿尔鑫.基因重组人红细胞生成素治疗各类贫血临床观察[J].现代诊断与治疗,1996,7(4):231-232.