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10-羟基-2-癸烯酸对小鼠T淋巴细胞及其亚型和白介素2产生的影响 被引量:19

Effects of 10-hydroxy-2-decenoic acid on T lymphocyte and its subtypes and interleukin 2 production in mice
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摘要 观察了10-羟基-2-癸烯酸(10-HDA)对小鼠T淋巴细胞及其亚型和白介素2产生的影响.结果表明,10-HDA1,5,25mg·kg-1·d-1ip,5d可拮抗环磷酰胺100mg·kg-1对小鼠迟发型超敏反应(DTH)的抑制作用.体外给药,10-HDA可促进刀豆球蛋白A诱导的T淋巴细胞增殖反应;促进小鼠脾细胞产生白介素2.采用单克隆抗体间接免疫荧光法证明10-HDA可增加小鼠胸腺L3T+4细胞数,而对Lyt-2+细胞无明显影响.结果提示10-HDA可调节T淋巴细胞参与的免疫反应. Hydroxy-2-decenoic acid (10-HDA), an unsaturated fatty acid, was extracted from royal jelly. The effects of 10-HDA was studied on T lymphocyte functions in mice. The results showed that 10-HDA (1, 5, 25 mg·kg -1 , ip×5 d) significantly antagonized the inhibition of delayed type hypersensitivity (DTH) induced by cyclophosphamide, but it had no effect on DTH in normal mice. The mitogen concanavalin A induced proliferation of T lymphocyte from the mouse spleen was increased by 50 and 100 mg·L -1 10-HDA in vitro. The effect of 10-HDA on the T subpopulation was studied by monoclonal antibody indirect immunofluorescence method. The results showed that 10-HDA (50 and 100 mg·L -1 ) enhanced the number of L 3T + 4 (T H) lymphocytes. 10-HDA (25, 50 and 100 mg·L -1 ) with concanavalin A increased the IL-2 secretion from mouse splenocytes in a concentration-dependent manner. These results suggested that 10-HDA had an immunomodulatory effect on T lymphocyte functions.
出处 《中国药理学与毒理学杂志》 CSCD 北大核心 1996年第1期53-55,共3页 Chinese Journal of Pharmacology and Toxicology
关键词 蜂王浆 癸烯酸 药理作用 T淋巴细胞 白细胞介素 hydroxy-2-decenoic acid delayed type hypersensitivity lymphocyte proli- feration T lymphocyte subsets interleukin-2
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