摘要
目的:探讨胰腺囊实性肿瘤(CSTP)的临床病理及免疫组化特点。方法:4例CSTP常规作HE染色免疫组织化学(S-P法)染色观察。结果:4例患者手术后均无复发。肿瘤较大,平均直径6.25cm,有包膜,由囊性与实性区混合组成。镜检:肿瘤细胞围绕纤维血管轴心排列成假乳头突起为其特征,细胞形态较一致,核圆形或卵圆形,异型性不明显,核分裂相罕见。免疫组化:4例AACT(+)。3例AAT(+),3例NSE(+),2例Vimentin(+),2例PR(+),1例Keratin局灶(+),Des、ER、S-100蛋白、Syn均(一)。结论:胰腺囊实性肿瘤多发生于年轻女性,具有独特的临床病理特点和较高的手术治愈率,应视为交界性肿瘤。
Objective： To study the clinicopathologic and immunohistochemical characteristics of cystic and solid tumors of the pancreas （CSTP）. Methods： 4 cases of CSTP were studied by histologic HE and immunohistochemistry （S-P method）. Results： There were 3 female and 1 male patients aged from 25 to 56 （mean age 38） without recurrence after tumor resection. The tumors were larger in size （mean diameter 6. 25cm）. All encapsulated, and solid alternately with cystic. Histologically, Psudopapillary structure with a fibrovascular core was remarkable. They were unformed population of cells, the nuclear was oval, round without atypia, and rate mitotic figures. Immunohistochemically, the tumors were positive for AACT（4 cases）, AAT （3 cases）, NSE（3 cases）, Vimentin （2 cases）, PR （2 cases）,Keratin （lcase）. but negative for Des,ER, S-100 and synaptophysin in all the cases. Conclusion：CSTP is a clinicopathologic entity in young female patients with a benign clinical course. It is a tumor of uncertain malignant potential （borderline）.
出处
《中国临床医学》
北大核心
2005年第4期717-718,共2页
Chinese Journal of Clinical Medicine
关键词
胰腺肿瘤
免疫组织化学
预后
Pancreatic neoplasms
Immunohistochemisty
Prognosis
