摘要
目的:通过建立缺血预适应(IP)模型,探讨IP对离体高血脂大鼠缺血再灌注(I/R)损伤的保护作用。方法:通过喂食高脂造型饲料建立高血脂大鼠模型,随机分成正常组和高血脂组,实验过程中每组再分为对照组、IP组、I/R组,测定各组的LVSP、dp/dtmax、ATPase、MDA、SOD、冠脉流出液的CK值。结果:经缺血预处理后明显减轻缺血再灌注损伤,与I/R组比较,正常大鼠和高血脂大鼠的CK减少22%和27%,MDA降低26%和20%,SOD升高12%和17%,ATPase升高41%和46%,LVSP升高35%和37%。结论:缺血预适应对离体高血脂大鼠缺血再灌注损伤同样有保护作用,保护程度与正常大鼠接近。
Objective： We intent to establish a ischemic precondition（IP） mode to study whether IP can protect high blood fat rats from ischemia/reperfusion injury. Methods： Rats are randomly divided into tow groups, one group for control, the other was raised with full fat food. Each group divided into three subgroups and treat with IP, I/R and control. LVSP, dp/dtrnax, ATPase, MDA, SOD and CK are detected. Results： On the mode of high blood fat rat heart, IP decreases CK and MDA and increases activity of SOD and ATPase, greatly increases LVSP. Conclusion： Ischemic precondition can protect high blood fat rats from ischemia/reperfusion injury.
出处
《中国临床医学》
北大核心
2005年第4期740-741,共2页
Chinese Journal of Clinical Medicine
关键词
高血脂
大鼠
再灌注
缺血预适应
Hyperlipaemia
Rat
Repertusion
Ischemic precondition
