摘要
为探讨肝硬化患者血清胃泌素水平与肝功能、门体分流指数(SI)的关系,检测40例肝硬化患者和10例正常对照者的血清空腹胃泌素水平及肝功能 Child 评分和 SI(用经直肠(99m)~Tc 门体循环显像术)。肝硬化患者胃泌素为183.27±67.42ng/L,显著高于正常对照组(92.00±41.00ng/L),P<0.001。肝硬化患者 Child A、B、C 3组胃泌素水平(ng/L)分别为142.24±22.60、191.69±25.82、219.82±36.40,其中 Child A 级胃泌素显著低于 B 级和 C 级(P 均<0.005),而 B 级与C级两组差异无显著性,且胃泌素水平与 SI、肝功能 Child 评分均呈正相关(r 分别为0.604、0.703)。证实肝硬化患者的高胃泌素血症主要与肝脏灭活减少和门体分流量增大有关。
PURPOSE This study was to evaluate the relation among the portosystemic shunt index (SI),hepatocellular func- tion and hypergastrinemia in liver cirrhosis.METHODS The fasting serum level of gastrin,liver function Child-pugh grade and SI were determined using ^(99m)Tc-pertechnetate per-rectal scintigrapby technique,in 40 patients with liver cirrhosis and 10 healthy vol- unteers.RESULTS The gastrin levels of patients (183.27±67.42ng/L) were significantly higher than those (92±41ng/L) of control subjects (P<0.001).Gastrin levels of Child grade A,B,and C cirrhosis were 142.24±22.60,191.69±25.82,and 219.82±36.40ng/L respectively (P<0.005,Grade A vs grade B and C,P>0.05,Grade B vs grade C).There were positive correlations between SI and gastrin levels (r=0.604) as well as between hepatocellular function tests (Child-pugh grade) and gas- trin levels(r=0.703).CONCLUSIONS It could be postulated that the impaired inactivation of gastrin in the cirrhotic liver and the presence of portosystemic shunt may be the main causes of hypergastrinemia in patients with liver cirrhosis.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
1996年第1期39-40,共2页
Chinese Journal of Nuclear Medicine
关键词
肝硬变
血清
胃泌素
肝功能试验
门体分流指数
Liver cirrhosis
Gastrins
Liver function tests
Portasystemic shunt index
