摘要
目的研究哌拉西林钠/舒巴坦钠(4∶1)体外抗菌活性。方法用琼脂平板二倍稀释法测定最低抑菌浓度(MIC)。结果哌拉西林-舒巴坦复方制剂(4∶1)对革兰阳性菌和革兰阴性菌均有较好抗菌活性。尤其对产酶甲氧西林敏感的金黄色葡萄球菌(MSSA)和甲氧西林敏感的表皮葡萄球菌(MSSE)、产酶流感嗜血杆菌和卡他莫拉菌、不产超广谱β内酰胺酶(ESBLs)与产ESBLs的大肠埃希菌和肺炎克雷伯菌、易产染色体诱导酶的阴沟肠杆菌、铜绿假胞菌和鲍曼不动杆菌的抗菌作用优于哌拉西林钠,其MIC50或MIC90为哌拉西林钠的1/2～1/32和1/2～1/64。产ESBLs的大肠埃希菌对哌拉西林钠/舒巴坦钠(4∶1)、头孢哌酮钠/舒巴坦钠、哌拉西林/他唑巴坦钠的敏感性分别为60.0%,66.7%和76.7%;而肺炎克雷伯菌的敏感性分别为56.7%,63.3%和63.3%;铜绿假胞菌的敏感性分别为72.0%,72.0%和76.0%;鲍曼不动杆菌的敏感性分别为76.0%,82.0%和52.0%。结论哌拉西林钠/舒巴坦钠是有效的β内酰胺酶抑制剂的复合制剂。
Objective To evaluate the antibacterial activity in vitro of piperacillin - sulbactam （ 4 ： 1 ）. Methods Minimal inhibitory concentrations （ MIC ） were measured by agar dilution method. Results Piperacillin - sulbactam（4：1 ） is an effective antibiotic containing β -lactamases inhibitor to the most gram - positive Cocci and gram - negative Bacillus in this study. The antibacterial activity of piperacillin - sulbactam （ 4 ： 1 ） , especially against methicillin susceptible Staphyloccus aureus and methicillin susceptible Staphyloccus epidermidis of producing β - lactamses, Haemophilus influenza and MoraxeUa catarrh of producing β - lactamses, E. coli and KlebsieUa pneumonia not producing extended spectrum β -lactamases （ESBLs ） , E. coli and KlebsieUa pneumonia producing ESBLs, E. cloacae easy to producing AmpC, Proteus mirabilis, Pseudomonas aeruginosa and Acinetobacter baumanii was better than piperacillin, the MIC50 or MIC90 respective was 1/2 - 1/32 or 1/2 - 1/64 of piperacillin. The susceptibility of piperacillin - sulbactam （4 ： 1 ） , cefperazone/sulbactam, piperacillin/tazobactam against E. coli producing ESBLs respective was 60. 0%, 66. 7% and 76.7%; KlebsieUa pneumoniae producing ESBLs respective was 56.7%, 63.3% and 63. 3%;Pseuclomonas aeruginosa respective was 72. 0%, 72.0% and 76.0% ;Acinetobacter baumanii respective was 76.0% ,82.0% and 52.0%. Conclusion Piperacillin - sulbactam（4：1 ） is an effective an- ti-biotic containing β lactamases inhibitor.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2005年第4期287-291,共5页
The Chinese Journal of Clinical Pharmacology
关键词
哌拉西林
舒巴坦
体外抗菌活性
piperacillin
sulbactam
in vitro antibacterial activity
