摘要
目的:对795例患者的肠外营养支持进行回顾性分析.方法:对行肠外营养支持的399例患者进行治疗前后淋巴细胞计数、血浆白蛋白和血浆锌离子浓度等营养学指标的比较,并选择行肠外营养的患者198例与行单一静脉营养的患者198例进行营养学指标的比较,同时比较不良反应和依从性.另选择25例有单一静脉营养史患者25例,分为足量组13例和低氮组12例,分别按照1.0～1.5和0.6 g·kg-1·d-1逐渐在3 d内递增到1.0～1.5 g·kg-1·d-1给予氨基酸,其余营养支持相同, 进行营养学指标的比较.结果:与治疗前比较,行肠外营养支持后患者的白蛋白、淋巴细胞计数、锌离子浓度等均显著增加(P<0.05).与单一静脉营养相比较,行肠外营养患者的白蛋白、淋巴细胞计数、锌离子浓度等也均显著增加(P<0.05),同时不良反应和依从性较好.足量组与低氮组比较,白蛋白值显著增加,而淋巴细胞计数、锌离子浓度无显著性差异.结论:肠外营养支持可以显著改善营养不良.
Objective：To analyze retrospectively the outcomes of parenteral nutritional support （PN）. Methods：399 patients who received enteral parenteral nutritional support （EN） were evaluated based on the lymphoeytes count, serum albumin and serum zinc levels prior to and post the nutritional support. 198 patients who had the EN were compared to 198 patients who were administered with the single venous nutritional support （VPN） in the nutritional index, safety profiles and compliance to the support. Additional 25 patients who had a history of the VPN were categorized into 13 patients who were given with sufficient PN and 12 patients who were supported with low nitrogen PN. The 13 patients were then supported with the EPN containing amino acids source of 1.0 - 1.5 g·kg^-1 daily, and the 12 patients were initially administered with the EPN containing amino acids source of 0.6 g·kg^-1 daily and gradually escalated up to 1.0 - 1.5 g·kg^-1 daily within 3 days. The nutritional index was assessed at the end of the support. Results：The EPN patients showed significant increases in the lymphocyte count, albumin and zinc ion level after the EPN support （ P 〈 0.05）. The EPN patients had more lymphocyte count, albumin and zinc ion levels, and showed better safety profiles and compliance to the support than the VPN patients （ P 〈 0.05 ）. The 13 patients experienced significantly higher albumin levels than the 12 patients. No statistical differences in the lymphocyte count and zinc ion levels were observed in both groups. Conclusion： The malnutritive patients may receive favorable benefits from the EPN support.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2005年第8期1067-1069,共3页
Chinese Journal of New Drugs
关键词
肠外营养
回顾性分析
单一静脉营养
白蛋白
淋巴细胞计数
锌离子浓度
enteral parenteral nutrition
retrospective analysis
single venous nutrition
albumin
lymphocyte count
zinc ion level
