摘要
目的观察评价重组酵母乙肝疫苗(YDV)接种后的安全性和免疫学效果。方法对某大学两组采用不同免疫剂量的新生(Ⅰ组:0.5μg×3和Ⅱ组:10μg×3),均按0、1、6个月程序作乙肝免疫注射,于第一针免疫注射后第12个月的HBsAb阳性率情况作统计分析。结果两组HBsAb阳转率分别是:Ⅰ组76.33%(329/431),Ⅱ组91.07%(367/403)。χ2=32.74,P<0.01,两组对比有显著性差异。两组在免疫注射后,局部和全身均未见不良反应。结论YDV对成人具有良好的免疫原性和安全性。采用较大剂量YDV对成人的免疫效果优于低剂量组。
Objective To observe and evaluate the safety and immunogenicity of recombinant yeastderived hepatitis B vaccine after inoculating it into students. Methods We divided these students into two groups which were adopted different immunization doses （The group Ⅰ were vaccinated with 0. 5 micrograms at beginning and the 1st and 6th month, and the group Ⅱ were vaccinated with 10 micrograms at beginning and the 1st and 6td month）, and then made a statistical analysis for the positive rate of HBsAb of the vaccinee at the 12th month. Result The positive rate of anti-HBs of group Ⅰ was 76.33% （329/431）, and group Ⅱ was 91.07% （367/403）, X^2=32.74, P〈 0.01, the difference between the two groups was obvious. There were no ill responses on local and whole body after vaccinating. Conclusion The YDV is effective and safety to adults. The immunization effect of the higher doses group was better than the lower one＇s.
出处
《国际医药卫生导报》
2005年第17期247-248,共2页
International Medicine and Health Guidance News
