摘要
(E)-4-氯-3-甲基-2-丁烯-1-醇乙酸酯经磺酰化、水解和THP保护羟基得到的四氢吡喃醚与茄呢基溴进行偶联,再脱除磺酰基和THP保护基得到癸异戊二烯醇,总收率54%,茄呢醇利用率77%。
Decaprenol was synthesized from （E）-4-chloro-3-methyl-2-butenol acetate by sulfonylation, hydrolysis, protection by THP to give tetrahydropyranyl ether, which to coupled with solanesyl bromide followed by desulfonylation and deprotection with an overall yield of 54% and utilization of solanesol was 77%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第9期529-531,共3页
Chinese Journal of Pharmaceuticals
