摘要
目的揭示肿瘤坏死因子(TNF),白细胞介素(IL-1)两种炎症因子与牙周疾病的关系。方法本实验采用免疫组织化学的方法,原位确定牙周组织结构的化学成分及化学性质,观察牙周组织炎症中 TNF-α和IL-1β存在,分布。结果TNF-α组以细胞浆内出现棕黄色颗粒为阳性细胞,单纯性牙周炎中可见点状棕黄染色,复合性牙周炎中阳性细胞胞浆棕黄染色较深;IL-1β以细胞膜和细胞浆中出现棕黄色颗粒为阳性细胞,牙周炎中的棕黄染色无明显差异。结论 TNF-α,IL-1β参与牙周炎症过程。
Objective To reveal the relationship of TNF-α, IL - 1 with Periodontitis.Methods With Immunohistochemistry method,determine the chemical compesition and quality, observe the exist and the distribution of TNF - α and IL - 1β in periodonfitis. Results In the TNF-α group, the positive cells are in cytoplasm, there are brown point in simple periodontitis and deepen brown point in complex periodontitis; In the IL- 1 group, the positive cells are in cytoplasm and cell membrane, there are no different coloration between different periodontitis.Conclusions TNF- α, IL- 1β participate the process of periodontitis.
出处
《医学研究通讯》
2005年第9期50-52,共3页
Bulletin of Medical Research
