摘要
目的探讨高血压合并肾损害患者血清β1肾上腺素受体(β1受体)和α1胆碱能受体(α1受体)自身抗体与血清肌酐水平的关系。方法以合成的α1受体和β1受体多肽片段为抗原,应用酶联免疫吸附测定(ELISA)技术检测了118例(高血压并肾损害60例,高血压无肾损害58例,正常对照40例)。结果高血压病并肾损害组抗β1和α1受体自身抗体阳性率分别为(67·9%、46·4%)明显高于高血压无肾损害组的19%和20·7%及正常对照组17·5%和15%(P<0·01)。结论抗G-蛋白偶联型受体自身抗体可能与高血压合并肾损害有关,与血清肌酐水平有关。
Objective To explore the role of the autoantibodies α1 muscarinic receptor（α1 receptor） and β1 adrenergie reeeptor（β1 receptor）in the development of hypertension with renal failure. Methods The epitopes of the second extraeellular loop of α1 receptor （192-218） and β1 receptor （197-222） were synthesized and used respectively to screen sera autoantibodies from patients with hypertension with renal failure （n= 60） , hypertension without renal failure （ n= 58 ） and healthy blood donors （ n = 40, control） by ELISA. Results The positive rates of the autoantibodies β1 receptor （67.9%） and α1 receptor （46.40%） in patients with hypertension with renal failure were higher than those of patients with hypertension without renal failure （19% and 20.7% respectively） （P〈0.01）, and they were also higher than those of healthy donors （15% and 17.5% respectively） （P〈0.01）. Conclusion The findings suggest that these autoantibodies β1 receptor and α1 receptor may play important roles in the pathogenesis of the hypertension with renal failure.
出处
《高血压杂志》
CAS
CSCD
北大核心
2005年第9期549-551,共3页
Chinese Journal of Hypertension
