摘要
深静脉血栓形成危险因素分为环境因素和遗传因素两部分,遗传因素决定了患者在环境因素作用下才会发生深静脉血栓。国内的一些局域统计资料发现我国的深静脉血栓形成的先天性致栓因素为抗凝血酶Ⅲ缺乏、蛋白C缺乏、蛋白S缺乏,尤其蛋白S缺乏可能是我国深静脉血栓的常见原因。这与西方国家的遗传因素不同,后者认为凝血因子Ⅴ突变和凝血酶原基因突变是其常见原因。而高同型半胱氨酸血症和血管紧张素转换酶基因多态性国内外认为均为深静脉血栓的独立危险因素。
Risk factors of deep venous thrombosis consist of congenital and acquired risks. Congenital risks are more important than acquired factors in determining overall thromboembolic risk. Deficiencies of antithrombin Ⅲ , protein C, protein S are common factors in Chinese. Factor V Leiden and the prothrombin G20210A gene mutation are common risks in west population. Hyperhomocysteinemia and the insertion/deletion angiotension converting enzyme gene polymorphism are independent risk factor for deep venous thrombosis at home and abroad.
出处
《心血管病学进展》
CAS
2005年第B08期54-57,共4页
Advances in Cardiovascular Diseases
关键词
深静脉血栓
遗传
Deep venous thrombosis
Congenital risks
