摘要
目的:探讨胃癌组织中的CGA、SY、GAS、SS、5-HT的表达及临床意义。方法:采用即用型免疫组化微波加热法对56例胃癌癌灶及癌旁3cm处正常胃组织中的CGA、SY、GAS、SS、5-HT等NE进行检测。结果:①胃癌旁3cm处正常胃组织中NE的CGA阳性表达率为55.35%(31/56),胃癌癌灶CGA阳性表达率为53.57%(30/56)。胃窦部以GAS多见,占55.55%(15/27);②不同组织学类型的胃癌中均有不等量的NE,分化差的胃癌中CGA和SY阳性表达率分别为52.50%(21/40)和30%(12/40);分化好的胃癌中CGA和SY阳性表达率分别为56.25%(9/16)和18.75%(3/16);③胃癌临床分期以Ⅲ期、Ⅳ期为多见,CGA阳性表达率分别为48.15%(13/27)和80%(4/5)。结论:胃内不同部位发生的胃癌中均见不等量的NE,并构成胃癌的成分;分化差及临床Ⅲ期、Ⅳ期的胃癌中含阳性表达的NE多见;在化疗前对胃癌的NE检测,有助于临床联合用药的合理选择及预后判断。
Objective： To observe the expression of CGA,SY,GAS,SS,5-HT in gastric cancer tissue. Methods： The gastric cancer samples were collected from our hospital between Jan 2003 and Jun 2004 by surgery. The CGA,SY,GAS,SS,5-HT from 56 samples （in gastric cancer core and paracancer 3cm normal gastric tissue） and NE were measured by immediate immunohistochemical microwave heating method. Results： The CGA positive expression was 55.35% and 53. 57% in the normal gastric tissue and the cancer tissue respectively. The CGA and SY positive expression in undifferentiated cancer was 52. 50% and 30. 0%; but 56. 25% and 18. 75% in differentiation. The CGA expression rate was 48. 15% and 80% in III and IV gastric cancer respectively. Conclusions： NE is the main content of gastric cancer. Expression of NE is more in II and IV gastric cancer. Our study is beneficial to treatment and prognosis of gastric cancer.
出处
《青海医药杂志》
2005年第8期1-4,共4页
Qinghai Medical Journal
关键词
胃癌
癌灶
癌旁
内分泌细胞
免疫组化
Gastric cancer
Expression
CGA
SY
Differentiation
Immunohistochemistry
