摘要
目的观察环丙沙星治疗实验感染动物鼠疫疗效。方法实验感染鼠疫24h后的新西兰白兔按每日每公斤体重0.04g,2次静脉注射环丙沙星。结果环丙沙星治疗组动物全部治愈,停药后9d处死,鼠疫细菌学培养阴性。结论环丙沙星可用于鼠疫的临床治疗。
Objective To observe the efficacy of ciprofloxacin in the treatment of animals with infected Yersinia pestis （Y. pestis ）. Methods New Zealand rabbits were experimentally infected with virulent Y. pestis. After 24 hours, they were intravenouly administered with ciprofloxacin twice a day at a dose of 0.04 g/kg. Results All animals used eiprofloxacin were alive. Nine days after withdrawal of the medication,the rabbits were sacrificed. The results of bacteria culture were all negative. Conclusions Ciprofloxacin can be used alone in the treatment of plague patients.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2005年第5期564-565,共2页
Chinese Jouranl of Endemiology
基金
西宁青海省科技厅攻关课题(项目编号:2003-N-131)
关键词
鼠疫
环丙沙星
治疗
疗效
Plague
Ciprofloxacin
Treatment
Efficacy
