期刊文献+

克拉霉素与紫色素的荷移反应及其测定 被引量:11

Spectrophotometric Determination of Clarithromycin Based on the Charge Transfer Reaction between Clarithromycin and Purpurin
下载PDF
导出
摘要 建立了一种测定克拉霉素的荷移分光光度法.克拉霉素与紫色素在乙醇溶液中发生电荷转移反应,荷移络合物在548nm处有最大吸收,表观摩尔吸光系数是4.49×103L*mol-1*cm-1, 该络合物的组成是1:1; 稳定常数是3.48×104;药物浓度在10~150 mg/L 范围内服从比耳定律.当克拉霉素浓度为100 mg/L时,6次测定结果的相对标准偏差为1.2%.利用本法测定了克拉霉素制剂中有效成分的含量,并与文献法进行比较,二者结果基本吻合,回收率在97.0%以上. A spectrophotometric method for the determination of clarithromycin has been developed based on the charge transfer reaction between clarithromycin as donor and purpurin as acceptor in alchol medium. The apparent molar absorptivity of complex is 4.49×10^3 L·mol^-1·cm^-1 at 548 nm, while the composition ratio and stability constant of charge transfer complex are 1 : 1 and 3.48×10^4 respectively. Beer's law is strictly obeyed in the range of 10 - 150 mg/L of clarithromycin. The average recovery is over 97.0% . The relative standard deviation of six determinations is 1.2% when the concentration of clarithromycin is 100 mg/L. The method has been applied to the analysis of some clarithromycin samples with satisfactory results. Compared with other common method, spectrophotometric determination is a more convenient method due to its cheap equipment and rapid measurement.
出处 《分析化学》 SCIE EI CAS CSCD 北大核心 2005年第9期1327-1329,共3页 Chinese Journal of Analytical Chemistry
  • 相关文献

参考文献7

二级参考文献19

  • 1林赴田.克拉红霉素的基础与临床评价[J].中国新药杂志,1994,3(2):7-11. 被引量:10
  • 2张敏波,张琪霞,金耀楚.罗红霉素片溶出度的分光光度测定[J].中国医药工业杂志,1996,27(6):260-261. 被引量:21
  • 3中华人民共和国药典委员会.中华人民共和国药典二部[M].北京:化学工业出版社,2000,附录VIII.J62-63.
  • 4[1]Baswaraj J, Ravisankar S, Vasudevan M, Suresh B. East Pharm., 1996, 39(462):127~128
  • 5[2]Reddy M N, Reddy M V V N, Sridevi D, Sushruta K, Sankar D G. J. Inst. Chem., 2000, 72 (1):32~35
  • 6[3]Zhang, Tieli, Zhao, Huichun, Jinpei. Talanta, 1999, 49 (1):77~82
  • 7[4]Yorke J C, Froc P. J. Chromatogr.A, 2000, 882(1-2):63~77
  • 8宋学勤,国外医药.抗生素分册,1997年,18卷,2期,119页
  • 9中华人民共和国药典委员会,中国药典.2,1995年,附录66页
  • 10Clear Elwell, Jem Hebden. Biomedical optics research group near-infrared spectroscopy [J]. Physics-Uspekhi,1997,40 (5).

共引文献66

同被引文献235

引证文献11

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部