摘要
目的:研究鹅不食草挥发油的抗炎作用及其可能的机制。方法:采用油酸合并脂多糖“两次打击”致大鼠急性肺损伤模型,观察鹅不食草挥发油对大鼠急性肺损伤的保护作用。结果:鹅不食草挥发油能显著抑制急性肺损伤所致大鼠肺水肿及中性粒细胞升高,抑制肺损伤大鼠支气管上皮细胞中CD54的表达。结论:鹅不食草挥发油对大鼠急性肺损伤有明显的保护作用,减少支气管上皮细胞CD54的表达是其抗吸呼道炎症作用的可能机制。
Objective: To study the anti-inflamation effect of Volatile oil of Centipesa minima and the mechanism of action. Method: The “Two-hit” animal model of acute lung injury in rats was induced by oleic acid and lipopolysaccharide, to observe the protective effect of VOCM on acute lung injury in rats. Result: VOCM was able to suppress lung edema and high numbers of neutrophils, decrease the expression of CD54 in the bronchial epithelium tissue in the acute lung injury animal models. Conclusion: VOCM has a protective effect on acute lung injury in rats. Decreasing the expression of CD54 in the bronchial epithelium tissue may be one of its mechanisms of against respiratory tract inflammation.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2005年第8期466-468,452,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
贵州省科委科学基金项目(20002)
