摘要
为了探讨应激状态下新生儿应用两种不同剂量脂肪乳剂时的脂肪代谢情况，以指导临床合理应用。将１７例胎龄＞３５周，手术后需ＴＰＮ＞１周的新生儿，随机分成低剂量脂肪乳剂组（１ｇ·ｋｇ^（－１）／ｄ）８例，普通剂量对照组（２ｇ·ｋｇ^（－１）／ｄ）９例。在ＴＰＮ前、ＴＰＮ第３天和第７天分别观察ＴＧ、ＴＣ、ＰＬ、ＦＦＡ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ、Ａｐｏ－Ａ_１和Ａｐｏ－Ｂ变化，结果低剂量组ＴＰＮ１周期间，ＴＧ、ＴＣ、ＰＬ变化不明显，而对照组ＴＧ、ＴＣ在ＴＰＮ第３天升高（但＜１．５０ｇ／Ｌ），第７天回到基值；ＰＬ持续升高，Ａｐｏ－Ａ_１／Ａｐｏ－Ｂ的比值１周变化为：低剂量组１．４７→１．６０→１．４１，对照组１．２０→０．８５→０．９６，它的变化与ＴＧ、ＴＣ等血脂变化相一致。从研究中得出，足月新生儿ＴＰＮ时选用１ｇ·ｋｇ^（－１）／ｄ对血脂几乎没有影响，用２ｇ·ｋｇ^（－１）／ｄ虽然有一过性升高，但仍＜１．５０ｇ／Ｌ，是安全的。
Seventeen neonates with gestational age over 35 weeks accepted TPN more than 1week after operation.They were divided into two groups,namely low dosage group,including 8 neonates with the dosage of fat emulsion 1g·kg-1/d,and normal dosage group,9 neonates withthe dosage of 2g·kg-1/d.During the lst week of TPN,TG(triglycerides),TC(total cholesterol),PL(phospholipid)didn't change in low dosage group,but elevated on 3rd day of TPN and dropped to baseline on 7th day in normal dosage group.PL kept elevating during the observation,The rate of Apo-A1 /Apo-Bchanged by 1.47→1.60→1.41 in low dosage group,and 1.20→0.85→0.96 in normal dosage group.They were in accordance with the change of TG and TC,We conclude the full-term neonates are tolerant of fat emulsion with the dosage of 1g·kg-1/d.The TG and TC temporarily elevated(below 150mg/dl) in normal group.Fat emulsion transfusion in newborns is safe.
出处
《中华小儿外科杂志》
CSCD
1996年第4期199-201,共3页
Chinese Journal of Pediatric Surgery
基金
国家自然科学基金
青年基金
