摘要
用小鼠可移植性组织细胞型淋巴瘤ＬⅡ接种于近交系６１５小鼠右后爪垫皮下，按宿主荷瘤时间以及肿瘤生长发展的不同阶段分期分批取血，检测荷瘤小鼠ＰＢＣ－Ｃ＿（３ｂ）ＲＲ和ＲＢＣ－ＩＣＲ，结合组织学观察，将肿瘤生长发展过程分为潜伏期，侵袭早、中、晚期，转移早、中、晚期等７个时期。观察ＲＢＣ－Ｃ＿（３ｂ）ＲＲ明显低于正常，并随肿瘤的发展呈下降趋势；而ＲＢＣ－ＩＣＲ高于正常，在肿瘤侵袭中期急骤增高，以后稳定在较高水平。提示：肿瘤的侵袭转移与宿主红细胞免疫功能下降有一定关系。实验组与正常组相比Ｐ＜０．０１＋实验组与瘤组相比Ｐ＜０．０１表２ 红细胞免疫复合物花环率（ＲＢＣ－ＩＣＲ）（Ｘ±ＳＤ）实验组与正常组相比Ｐ＜０．０１＋＋实验组与死瘤组相比Ｐ＜０．０１从表中可见，肿瘤移植后第１天为潜伏期，第３天为侵袭早期，第５天为侵袭中期，第１０天为侵袭晚期，此期开始出现引流淋巴结的肿瘤转移，故又为转移早期。第２０天非引流淋巴结表现转移为转移中期，第３０天出现肺转移为转移晚期。从表中可见，肿瘤移植后第１天，ＲＢＣ－Ｃ３ｂＲＲ开始就低于正常，并随着肿瘤的发展而逐渐降低，阴性对照组则与正常组无显著性差异；ＲＢＣ－ＩＣＲ在肿瘤移植后第５天开?
Red blood cells(RBC) of inbred 615 mice were studied for the RBC-C_(3b) receptor rate(RBC-C_(3b)RR)and RBC immune complex ratio(RBC-ICR)following implantation of the lymphoma LII into the right footpads.Blood was taken from the vein of the eyes of mice.The RBC-C_(3b)RR in the tumor-bearing group was significantly lower than that of the control group. It decreased gradually during the development of the tumor.However.RBC-ICR in the tumor-bearing group was higher than that of the control group. It increased rapidly during the latent, early and middle invasive stages and thence it maintained at a higher level at the metastatic stage.It is suggestive that there is correlation between the RBC immune deficiency of the hosts and the invasive and metastatic stage of the tumor.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1996年第5期353-355,共3页
Chinese Journal of Clinical Oncology
