摘要
目的探讨P-选择素(Ps)在脑梗死发生、发展中的作用。方法采用ELISA测定54例脑梗死患者、15例脑出血患者、20例正常对照血清Ps含量。结果脑梗死组发病3d内血清Ps水平明显高于脑出血组及对照组,后两组无显著差异;脑梗死组发病3d内血清Ps水平与发病后1周无显著差异,但均明显高于发病后2周,发病后2周与对照组无显著差异;脑梗死组发病3d内血清Ps水平与梗死灶体积呈正相关。结论Ps参与脑缺血再灌注损伤,可作为脑梗死早期诊断及鉴别诊断的依据,干预其产生和作用途径可改善脑梗死的预后。
Objective To explore the effects of P- selectin （Ps） on the occurrence and development of cerebral infarction （CI） Methods The serum level of Ps was detected by enzyme- linked immunosorbent assay （ELISA） in 54 patients with CI, 15 patients with cerebral haemorrhage and 20 normal controls. Results The serum level of Ps of CI group within 3 days after attack was significantly higher than those of cerebral haemorrhage and control groups. There was no significant difference between the laters. There was no significant difference between the level of Ps of CI group within 3 days after attack and that within 1 week. But both of them were higher tha.n that within 2 weeks with significant difference.There was no signifieant difference between the levels of Ps of CI group within 2 weeks after attack and control group. The serum level of Ps of CI group within 3 days after attack was positively correlated with the volume of infarcts. Conclusion Ps is involved in cerebral - ischemia - reperfusion injury and can be the basis of ealy pathogenesis and differential pathogenesis of CI. Interferring with its production and effects may improve the prognosis of CI.
