摘要
目的:研究分析癌性贫血患者血清促红细胞生成素(erythropoietin,EPO)水平与血红蛋白(Hb)水平之间的关系,指导临床治疗癌性贫血。方法:对135例癌症患者检测血清EPO及血常规,用化学发光免疫分析法检测血清EPO含量,以直线相关分析EPO水平与Hb之间的关系。结果:正常人血清EPO水平为(18.0±7.36)U/L;癌症患者血清EPO中位数(四分数)为26.50(15.9,56.5)U/L;癌症贫血患者血清EPO中位数(四分数)男性为35.7(16.55,74.55)U/L,女性为44.6(17.3,86)U/L。癌性贫血患者组血清EPO水平高于不伴贫血的癌症患者组和正常人群对照组,P=0.000。肿瘤患者血清EPO与同时检验的Hb水平存在负相关性,r=-0.576。癌症贫血患者EPO水平与1周后Hb升高值之间进行直线相关分析,r=0.381,呈正相关。结论:癌性贫血患者血清EPO高于正常人群血清EPO水平,反映机体自身调节功能,监测EPO对于临床应用人rhEPO治疗癌性贫血有指导意义。
OBJECTIVE： To study the relationship between levels of serum erythropoietin （EPO） and haemoglobin （Hb）in patients with anemia of cancer. METHODS：A total of 135 patients with cancer were detected for serum EPO and Hb. EPO in sera was detected with the chemiluminescent immunoassay and the relationship between EPO and Hb was analyzed with the linear correlation method. RESULTS： The level of serum EPO in normal group was （18.0±7.36） U/L. The level of serum EPO in cancer patients was 26.50 （15.9.56.5） U/L. The level of that in male cancer patients with anemia was 35.7 （ 16. 55,74.55） U/L. in female cancer patients with anemia was 44.6（17.3.86） U/L. The level of serum EPO in cancer patients with anemia was higher than that in cancer patients without anemia, and the level of serum EPO in cancer patients group was higher than that in normal group,P= 0.000. A negative linear correlation was found between the level of EPO and Hb in cancer patients with anemia, r =-0. 576. After a week. the level of Hb in EPO≥100 U/L group was higher than that in EPO〈100 U/L group. The linear correlation between the level of EPO and the increased Hb after a week was positive, r= 0. 381. CONCLUSION：There are increased endogenous EPO levels in cancer patients with anemia, which suggests that it is valuable for treatment to detect serum EPO levels in cancer patients with anemia.
出处
《肿瘤防治杂志》
2005年第17期1304-1306,共3页
China Journal of Cancer Prevention and Treatment
