摘要
目的研究阿魏酸在大鼠各肠各段的吸收动力学特征.方法采用大鼠在体肠回流实验装置,采用UV法和HPLC法分别测定肠循环液中酚红和阿魏酸的量.结果阿魏酸在大鼠小肠各段的吸收速率常数(ka)于阿魏酸不同质量浓度(20、50、100、200μg/mL)时分别为0.433 4、0.469 7、0.452 1、0.430 2 h-1;不同pH值7.8、6.8、5.4时分别为0.254 1、0.602 1、1.200 6 h-1;在不同肠段十二指肠、空肠、回肠、结肠时分别为0.151 2、0.178 4、0.168 7、0.066 9 h-1.结论药物质量浓度对ka无影响;在pH值为5.4～7.8,随药物溶液pH值的减小,药物ka显著增加;药物在十二指肠、空肠和回肠的吸收较好,在结肠的吸收较差;阿魏酸在肠道的吸收呈一级动力学过程,吸收机制为被动扩散.
Objective To investigate the absorption kinetics of ferulic acid at different intestine segments in rats. Methods The intestine in rats was cannulated for in situ recirculation. UV and HPLC were used to determine the concentrations of phenol red and ferulic acid, respectively. Results The absorption rate constants （ka） at the concentration of 20, 50, 100, and 200μg/mL from intestine were 0. 433 4, 0. 469 7, 0. 452 1, and 0. 430 2 h^-1, respectively, ka at pH value of 7.8, 6.8, and 5.4 from intestine were 0. 254 1, 0.602 1, and 1. 200 6 h^-1, respectively; ka at duodenum, jejunum, ileum, and colon were 0.1512,0.1784,0.0687,and 0.0669 h^-1, respectively. Conclusion Concentration has no effect on the absorption kinetics. And within pH value 5.4-7.8, the absorption of the drug is increased when pH value of the drug solution is lowered. Ferulic acid is better absorbed at duodenum, jejunum, and ileum than at colon. The absorption of ferulic acid is a first-order process with the passive diffusion mechanism.
出处
《中草药》
CAS
CSCD
北大核心
2005年第10期1514-1517,共4页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(30200363)
辽宁省博士启动基金资助项目(2001102042)
关键词
阿魏酸
吸收动力学
肠
ferulic acid
absorption kinetics
intestine
