摘要
目的:探讨抑癌基因E钙黏蛋白(Ecad)在食管癌组织中的表达及其与临床病理特征和患者生存期的关系.方法:应用免疫组化SP法检测67例食管癌组织中Ecad的表达,并分析其与食管癌临床病理特征和淋巴结转移及患者生存期的关系.结果:食管癌组织中Ecad的表达水平明显高于正常组织(34/67vs6/31,P<0.01),异常表达率为50.8%;食管癌Ecad表达与食管癌的分化程度、浸润深度、淋巴结转移及患者的生存期密切相关(P均<0.05),而与患者的年龄、性别、肿瘤的大小、部位和形态无关(P>0.05).结论:Ecad异常表达与食管癌的发生发展密切相关,是判断食管癌侵袭转移及预后的一个重要指标.
AIM： To explore the expression of E-cadherin （E-cad） in esophageal carcinoma and its relation to clinicopathological features and patient＇s survival. METHODS： The expression of E-cad in esophageal carcinoma was detected by immunohistochemical technique and its relationship to clinicopathological features and patient＇s survival was analyzed. RESULTS： The expression of E-cad was significantly higher in esophageal carcinoma tissue than that in normal mucosa （34/67 vs 6/31, P 〈 0.01 ）. E-cad abnormal expression was significantly correlated with the tumor differentiation, depth of invasion, lymph node metastasis and survival in 67 cases of esophageal carcinoma（ P 〈 0.05） but its relationship to age and gender of patient, and the size, location and gross appearance of tumor was not found （ P 〉 0.05）. CONCLUSION： The abnormal expression of E-cad in esophageal carcinoma may be associated with the carcinogenesis. E-cad can be used as a important marker for predicting the metastasis potential of esophageal carcinoma and the Droanosis.
出处
《第四军医大学学报》
北大核心
2005年第18期1664-1667,共4页
Journal of the Fourth Military Medical University
基金
甘肃省自然科学基金资助项目(ZS025A25067Y)
关键词
钙黏附糖蛋白类
食管肿瘤
免疫组织化学
肿瘤侵润
肿瘤转移
cadherins
esophageal neoplasms
immunohistochemistry
neoplasms invasiveness
neoplasms metastasis
