摘要
目的:探讨抑癌基因P33ING1在宫颈癌中表达的临床意义及其与P53相互关系.方法:应用Envision免疫组化法检测宫颈癌50例,宫颈不典型增生15例患者P33ING1和P53基因蛋白的表达,并与正常宫颈及宫颈炎组20例进行对照.结果:对照组及宫颈不典型增生组织中P33ING1均呈阳性表达(100%),而宫颈癌组中表达率明显下降62.0%,与前两组之间差异有显著性(P<0.01);且宫颈癌组中P33ING1表达与肿瘤、淋巴结转移及分化有关(P<0.01).结论:宫颈癌组织P33ING1表达明显下降,并与P53蛋白的表达呈负相关.
AIM： To explore the clinical signification of p33ING1 in carcinoma of cervix and the relationship between P^331NG, and P^53. METHODS： Using envision immunohisto chemical method, the expression level of P^33ING1, and P^53 was examined in 50 cases of cervix cancer, 15 cases of cervical intraepithelial neoplasm （CIN） group and 20 cases of control group. RESULTS： P^33,NG, expression in CIN group and control group was positive （ 100% ） and the expression in cervix cancer group was significantly lower （, 62.0% ） than that in the other groups （ P 〈 0.01 ）. P^33ING1 expression in cervix cancer was related to the lymphnode metastasis and tumor polarization （ P 〈 0.01 ）. CONCLUSION： P^33ING1 expression in cervix cancer is low and P^33ING1 is related to P53 expression in cervix cancer.
出处
《第四军医大学学报》
CAS
北大核心
2005年第18期1683-1684,共2页
Journal of the Fourth Military Medical University
基金
河南省自然科学基金课题(411042900)
