摘要
胃癌的发生是多种因素交互作用的结果,通过研究,作者发现在胃黏膜癌变的过程中,存在基因不稳,高甲基化,端粒丢失,错配修复基因和kras基因突变APC、MCC、DCC等抑癌基因的杂合性缺失以及细胞增殖和凋亡失衡等因素。维甲酸、亚硒酸钠、丁酸钠、表没食子儿茶素等具有防治胃癌的作用,基因治疗可以部分逆转胃癌细胞的恶性表型。
Gastric cancer is a result of interaction of multiple factors. In previous studies it was found that genetic instability, abnormality of DNA methylation, telomere loss, mismatch of repair gene and k-ras mutation, loss of heterozygosity （LOH） of some of cancer-inhibitory genes such as APC, MCC and DCC, disbalance between cell proliferation and apoptosis, etc. were associated with the development of gastric cancer. It was also discovered that tretinoin, sodium selenite, sodium butyrate and epigallocatechin-3- gallate （EGCG） may be effective in preventing gastric carcinoma and gene therapy may partially reverse the malignant phenotype of gastric cancer cells.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2005年第9期768-772,共5页
Medical Journal of Chinese People's Liberation Army
关键词
胃肿瘤
分子机制
防治
stomach neoplasms
molecular mechanisms
prevention and treatment
