摘要
目的探讨大鼠骨骼肌对中等负荷耐力训练的适应性变化。方法40只雄性Wistar大鼠进行上坡跑中等负荷运动,观察不同训练阶段大鼠比目鱼肌的超微结构和IGF1表达的变化。结果组织病理学观察示大鼠比目鱼肌发生了运动性肌肉损伤,且在第3周时损伤最重,出现骨骼肌结构相对“薄弱期”。同时,肌组织中IGF1水平明显升高。肌组织在损伤后即开始自行修复,运动4周后,Z线异常率和IGF1水平逐渐降低,病理改变逐渐减轻。结论肌肉损伤有一个逐渐加重后经修复逐渐减轻的过程,说明在损伤积累的同时,肌肉表现出良好的适应能力。
Objective To study the adaptability of rat skeletal muscle to medium load on endurance training. Methods 40 male Wistar rats were used in an upward-slope running with medium load. Then the ultrastructural changes of the soleus muscle and IGF-1 expression in different training stages were observed. Results The pathologic change of muscular tissues suggested that there was kinesic injury in rat soleus muscle, and the injury happened most seriously in the third week, when muscle structure experienced a relative ‘fragile’ period. At the same time, there was an obvious increase of IGF-1 in muscular tissues, which indicated that the muscle started to repair of itself immediately after injury. The abnormity rate of Z-cure and IGF-1 level began to decline gradually after 4 weeks, meanwhile the pathologic change reduced. Conclusion After been injured, the pathologic changes of muscle underwent a course of going serious then reducing accompanied with the reparation. The fact indicated that rat skeletal muscle showed a good adaptability to the injury accumulation.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2005年第9期850-851,共2页
Medical Journal of Chinese People's Liberation Army
基金
全军"十五"医药卫生科研指令性课题(编号01L005)
关键词
肌
骨骼
耐力训练
超微结构
胰岛素样生长因子
muscle, skeletal
endurance training
ultrastructure
insulin-like growth factor
