摘要
目的:就近几年国外有关磁共振波谱分析的基本原理及在脑卒中中应用方面的研究近况,综述磁共振波谱的基本原理及在脑卒中中的应用。资料来源:应用计算机检索Meline1990/2005与磁共振波谱的基本原理、磁共振波谱在脑卒中应用相关的文章,检索词为“MagneticResonanceSpectroscopy,Stroke”,“MagneticResonanceSpectroscopy,Metabolism”,并限定文章语言种类为“English”。资料选择:对资料进行初审,选取有关磁共振波谱及在脑卒中应用方面的相关文献,然后筛除明显不随机临床试验的研究,对剩余的文献查找全文,纳入标准为随机对照临床研究(RCT),无论是否为单盲,双盲或非盲法。资料提炼:共收集到相关文献28篇,排除10篇重复的同一研究,对剩余的18篇进行综述。资料综合:18篇文献,共包括78例患者。说明了磁共振波谱的基本原理,并介绍了脑1H-磁共振波谱共振峰种类与意义,磁共振波谱在脑梗死中的应用。总结了脑梗死时脑内代谢物的变化情况,认为脑梗死时,乳酸、高能磷酸盐和pHi的波动有一定规律性,梗死灶内乳酸的含量与梗死灶体积、局部脑血流量和临床神经功能评分相关。结论:应用磁共振波谱可以观察脑卒中后患者脑内代谢的变化,了解病情的严重程度,并对脑梗死进行预后推测。
OBJECTIVE： To review the basic theory of magnetic resonance spectroscopy （MRS） and its application on stroke by recent overseas situation of researching on the basic theory of MRS and its application on stroke. DATA SOURCES： We searched Medline for pertinent literature on the basie theory of MRS and its application on stroke published from 1990 to 2005, with the key words “Magnetic Resonance Spectroscopy,Stroke”, “Magnetic Resonance Spectroscopy, Metabilism”, and limited the language to English. STUDY SELECTION： After the first selection, the related literatures on MRS and its application on stroke were collected, and the obvious non-randomized researches on clinical trial were excluded, and the rest literatures were searched for the full text. Inclusion criteria： Randomized controlled clinical trial, no matter single blind, double blind or non-blind method. DATA EXTRACTION： Totally 28 related articles were collected. Ten articles on repetitive researches were excluded, and the rest 18 articles were reviewed. DATA SYNTHESIS： Of the 18 articles, there were 78 cases. The basic theory of MRS was indicated. The classification and significance of resonance peak of brain ^1H-MRS and the application of MRS in cerebral infarction were recommended. The change condition of metabolite in brain during cerebral infarction was summed up. It was thought that the fluctuation of lactic acid, high-energy phosphate and phi had certain regularity. The content of lactic acid in the infarcted focus had relation with volume of infarcted focus, regional cerebral blood flow and score of clinical neural function. CONCLUSION： The application of MRS can observe the changes of metabolism in internal brains of patients with stroke, know the severity degree of patients＇condition, and suspect on prognosis of cerebral infarction.
出处
《中国临床康复》
CSCD
北大核心
2005年第33期111-113,共3页
Chinese Journal of Clinical Rehabilitation
