2Calogero A, Arcella A, De Gregorio G, et al. The early growth response gene EGR-1 behaves as a suppressor gene that is downregulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas. Clin Cancer Res, 2001, 7 : 2788-2796.
3Watanabe T, Katayama Y, Yoshino A, et al. Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course. Clin Cancer Res,2003, 9 : 4884-4890.
4Watanabe T, Nakamura M, Yonekawa Y, et al. Promoter hypermethylation and homozygous deletion of the pl4ARF and p16INK4a genes in oligodendrogliomas. Aeta Neuropathol ( Berl),2001, 101 : 185-189.
5Perry A, Anderl K, Borell TJ, et al. Detection of pl6, RB, CDK4,and p53 gene deletion and amplification by fluorescence in situ hybridization in 96 gliomas. Am J Clin Pathol, 1999, 112: 801-809.
6Suzuki T, Maruno M, Wada K, et al. Genetic analysis of human glioblastomas using a genomic microarray system. Brain Tumor Pathol, 2004, 21: 27-34.
7Nishikawa R, Sugiyama T, Nafita Y, et al. Immunohistochemical analysis of the mutant epidermal growth factor, delta EGFR, in glioblastoma. Brain Tumor Pathol, 2004, 21 : 53-56.
8Mizoguchi M, Nutt CL, Mohapatra G, et al. Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas.Brain Pathol, 2004, 14 : 372-377.
9Fiano V, Ghimenti C, Imarisio S, et al. PAkt, cyclin D1 and p27/Kipl in glioblastomas with and without EGFR amplification and PTEN mutation. Anticancer Res, 2004, 24(5A) : 2643-2647.
10Park KH, Lee J, Yoo CG, et al. Application of p27 gene therapy for human malignant glioma potentiated by using mutant p27. J Neurosurg, 2004 , 101: 505-510.
7Steinbach JP, Weller M. Apoptosis in gliomas: molecular mechanisms and therapeutic implications. J Neurooncol, 2004,70 : 245 -254.
8Campioni M, Santini D, Tonini G . Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance. Exp Dermatol, 2005,14 : 811-818.
9Soengas MS, Capodieci P, Polsky D,et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature,2001, 409:207-211.
10Zou H, Henzel WJ, Liu XS, et al . Apaf-1, a human protein homologous to C.elegans CED-4,participates in cytochrome c-dependent activation of caspase-3.Cell,1997,90:405-413.
