摘要
目的研究连续性血液净化治疗(CBP)对多器官功能衰竭患者循环Th1/Th2的影响。方法36例多器官功能障碍综合征(mu ltip le organ dysfunction syndrom e,MODS)患者行CBP治疗。采用中心静脉留置单针双腔导管建立血管通路,采用Prism a连续性血液净化系统、以及配套的M60管路和滤器AN69(PAN膜,2.0 cm2)进行前稀释连续性静脉-静脉血液透析滤过(CVVHDF)。治疗前及治疗后24,48,72 h采血检测Th1/Th2。结果30例患者肾功能均恢复正常。在CBP治疗开始后24 h血Th1/Th2比值逐渐上升,48 h下降后有显著差异,72 h接近正常。24 h时与开始前比较,72 h与24 h比较有非常显著性差异(P<0.01)。结论CBP治疗可能可改善细胞免疫功能。
Objective To study the effects of continuous blood purification on Th1/Th2 in MODS patients. Methods A total of 36 patients with multiple organ dysfunction syndrome （MODS） were treated with continuous blood purification（CBP）. The vascular access established with two-lumen indwelling catheter in venae profundae or internal arteriovenous fistula, and Prisma（Hospal） system for continuous venovenous hemodiafthration （CVVHDF） , the Gambro AN69 dialyzers with polyacrylonitrile（PAN） membrane were used. Th1/ Th2 in plasma was checked before CBP and on 24 h, 48 h, 72 h after CBP. Twenty healthy subjects were employed as control. Results The renal function of 30 patients was recovered. The plasma Th1/Th2 was increased progressively in 24 h after CBP, reached nearly normal at 72 h. There was significant difference in plasma TH1/Th2 at 24 h after CBP as compared with that before CBP, at 72 h as compared with that at 24 h （P 〈 0.01）. Conclusion Continuous blood purification may improve cell immune function.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2005年第18期1877-1879,共3页
Journal of Third Military Medical University
