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微片的研究与应用概述 被引量：8

Research and development of mini-tablets
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摘要 目的介绍近年来国内外微片剂型的研究进展。方法根据已有文献,对其进行综合、分析与归纳。结果与结论微片在临床效果上类似于微丸,同属剂量分散型给药范畴;在制备工艺上,微片具有普通片剂的一般特征,但需要特殊的压片模具,并要求压片颗粒或粉末具有更好的流动性。微片的研究和应用主要以口服制剂为主,尤其适用于治疗剂量和毒性剂量比较接近,或给药剂量需根据患者血药浓度随时调整的药物。目前也用于眼科疾病的治疗。
作者 黄健 高春生 单利 梅兴国
机构地区 军事医学科学院毒物药物研究所
出处 《中国药学杂志》 CAS CSCD 北大核心 2005年第19期1441-1444,共4页 Chinese Pharmaceutical Journal
关键词 微片 模具 流动性
分类号 R943.4 [医药卫生—药剂学]
  • 相关文献

参考文献22

  • 1Mielck JB, Lennartz P. Minitabletting: improving the compactability of paracetamol powder mixtures [ J]. Int J Pharm, 1998,173 ( 1-2 ) :75.
  • 2Weyenberg W, Vermeire A, Remon JP, et al. Characterization and in vivo evaluation of ocular bioadhesive minitablets compressed at different forces[ J]. J Controlled Release, 2003,89(2) :329.
  • 3Weyenberg W, Vermeire A, Remon JP, et al. Development and evaluation of sustained release ocular minitablets[J]. J Controlled Release,2005,101(1-3) :371.
  • 4Fredholm BB, Sjoqvist F. Pharmacology at the start of a new millennium. Larger assortment and individual drug dosing are coming[ J ].Lakartidningen, 2001,98(6) :534.
  • 5Flemming J, Mielck JB. Experimental micro tableting: construction of an instrumented punch holder for an eccentric tabletting machine[ J].Eur J Pharm Biopharm, 1995,42(2) :212.
  • 6Rey H, Wagner KG, Wehrle P, etal. Development of matrix-based theophylline sustained release microtablets[ J]. Drug Dev Ind Pharm,2000,26(1):21.
  • 7Brabander C, Vervaet C, Fiermans L, et al. Matrix mini-tablets based on starch: microcrystalline wax mixtures[J]. Int J Pharm,2000,199(2): 195.
  • 8Flemming J, Mielck JB. Requirements for the production of micro tablets: Suitability of direct-compression excipients estimated from powder characteristics and flowrates[J]. Drug Dev Ind Pharm, 1995,21 (19): 2239.
  • 9Bredenberg S, Nyholm D, Aquilonius SM, et al. An automatic dose dispenser for microtablets-a new concept for individual dosage of drugs in tablet form[J]. Int J Pharm, 2003,261(1-2):137.
  • 10Hershberg EB. Apparatus for punching miniature tablets[P] .US,Patent 317552130, March, 1965.

同被引文献85

  • 1李国锋,陈建海,陈志良.结肠定位给药技术研究进展[J].中国药房,2005,16(1):64-66. 被引量：5
  • 2田娟,王智民,王维皓.HPLC测定苦参药材中苦参碱和氧化苦参碱的含量[J].中国实验方剂学杂志,2006,12(2):23-24. 被引量：35
  • 3李瑛,刘伏友.大黄的毒副作用研究[J].中国药房,2006,17(9):710-712. 被引量：14
  • 4[2]Lopes CM,Lobe JM,Pinto.JF,et al.Compassed mini-tablets as a biphasie delivery system[J].Int J Pharm,2006,323(1/2):93-100.
  • 5[3]Lennzrts P,Mielek JB.Mirtitablctting:improving the compactability of paracetamol powder mixtures[J].Int J Pharm,1998,173(1/2):75-85.
  • 6[4]Rouge N,Cole ET,Doelker E,et al,Buoyancy and drug release patterns of floating minitablets containing piretanide and atonolol as model drugs[J].Pharm Dev Technol,1998,3(1):73-84.
  • 7[6]Bredenberg S,Nyholm D,Aquilonius SM,et al.An automatic dose dispenser for mierotablets-a new concept for individual dosage of drug in tablet form[J].Int J Pharm,2003,261(1/2):137-146.
  • 8[7]Leane MM,Cumming I,Corrigan OI.The use of artificial neural networks for the selection of the most appropriate formulation and processing variables in order to predict the in vitro dissolution of sustained release minitablets[J].AAPS Pharm Sci Tech,2003,4(2):E26.
  • 9[8]Podezeck F,Course N,Newton JM,et al.Gastrointestinal transit of model mini-tablet controlled release oral dosage forms in fasted human volunteers[J].J Pharm Pharmacol,2007,59(7):941-945.
  • 10[9]Damle B,Ullah I,Doll W,et al.Pharmacokineties and gamma scintigraphy evaluation of two enteric coated formulations of didanosine in healthy volunteers[J].Br J Clin Pharmacol,2002,54(3):255-261.

引证文献8

二级引证文献11

中国药学杂志
2005年 第19期

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