摘要
目的探讨心舒口服液治疗动脉硬化,抑制血管平滑肌增生和抗血小板聚集作用。方法通过血清药理学方法,考察心舒口服液对大鼠血管平滑肌体外增殖作用及家兔体外血小板聚集功能的影响。结果心舒口服液不同时间点含药血清能够明显抑制血管平滑肌细胞的增殖,对花生四烯酸(AA)和ADP诱导的体外血小板聚集功能均有明显的抑制作用。结论心舒口服液治疗心肌缺血作用机制与抑制血管平滑肌细胞增殖和抗血小板聚集有关。
OBJECTIVE To study the anti-arteriosclerosis mechanism of Xinshu oral liquid.METHODS By serum pharmacology method, the effects of serum contained Xinshu oral liquid on rat aorta smooth muscle cell proliferation and rabbit platelet aggregation were investigated in vitro. RESULTS The serum contained Xinshu oral liquid at different time points obviously inhibited the proliferation of aorta smooth muscle cell and the platelet aggregation induced by arachidonic acid and ADP. CONCLUSION The anti-ischemia mechanism of Xinshu oral liquid is concerned with the inhibition of the aorta smooth muscle cell proliferation and platelet aggregation.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2005年第19期1466-1469,共4页
Chinese Pharmaceutical Journal
