摘要
３组１２只兔双眼行玻璃体切除术，分别于一眼玻璃体内注入０．５、１．０、２．０ｍｇ去炎松悬液，另一眼注入眼用平衡盐液。观察术后２８天内眼底及ＥＲＧｂ波和２８天时视网膜结构的变化。注入各剂量的去炎松在２８天时均未完全吸收，０．５、１．０ｍｇ组用药眼ＥＲＧｂ波在各时间点与对照眼及术前无显著差异（Ｐ＞０．０５）；２．０ｍｇ组用药眼较术前无显著差异（Ｐ＞０．０５），较对照眼有轻度升高（ｔ＝３．３５８９，Ｐ＞０．０５）。光镜及电镜下视网膜结构无损害。
Oneeyeeachin3groupsof12pigmentedrabbitsafterbilateralvitrectomyreceived0.5mg,1mgor2mgtriamcinoloneacetonide(TA),respectively.Thefeloweyereceivedonlyba-lancesalinesolutionascontrol.Ophthalmoscopyandelectroretinographywereperformedduring1dayto28daysaftervitrectomyanddruginjection.Lightandelectronmicroscopicstudiesweredoneonthe28thday.Theparticlesofdrugwerevisibleonday28inalTA-treatedeyes.Administrationof0.5mgand1mgTAdidnotresultindifferentchangesinERG-bwaveamplitudescomparedwiththoseincontroleyes(P>0.05).ThereweresignificantelevationsofERGb-wavein2mgTAeyescomparedtothecontroleyes(P<0.05).Bothlightandelectronmicroscopyoftheretinainthesegroupswerealmostnormal.TheresultsshowednotoxicitiesinTA-treatedeyeupto2mgaftervit-rectomy.ThisoferstheexperimentalevidenceasabaselineforcombiningTAwithvitrectomytoreducerecurrenceofproliferativevitreoretinopathy.
出处
《中华眼底病杂志》
CAS
CSCD
1996年第2期105-107,共3页
Chinese Journal of Ocular Fundus Diseases
基金
国家自然科学基金
关键词
PVR
玻璃体切除
视网膜电图
超微结构
去炎松
Triamcinolone/therapeuticuseRetina/drugefectRetina/ultrastructureElectroretinographyRabbits
