摘要
我们以ＣＴＸ＋ＶＣＲ＋ＭＴＸ＋ＤＤＰ（ＣＯＭＰ）和ＤＤＰ＋ＢＬＭ＋ＭＴＸ（ＰＢＭ）两种化疗方案治疗复发和转移的晚期鼻咽癌５８例。４９例可评价客观疗效。结果ＣＯＭＰ组取得ＣＲ３例、ＰＲ９例，有效率（ＣＲ＋ＰＲ）为５２．２％；ＰＢＭ组ＣＲ１例、ＰＲ９例，有效率（ＣＲ＋ＰＲ）为３８．５％。两者无显著性差异（Ｐ＞０．０５）．治疗后有效病例缓解期为５～５６月，中位缓解期为２５月。两种方案对鼻咽癌肺转移均较好，对肝转移疗效最差。ＣＯＭＰ方案对鼻咽癌远处转移疗效较好，对肺转移有效率为５８．３％（７／１２）．可作为鼻咽癌远处转移尤其是肺转移的首选。ＰＢＭ方案对鼻咽癌原灶复发疗效较好，对鼻咽癌复发有效率为４２．９％（３／７），可作为鼻咽癌原灶复发或放射治疗后辅助化疗首选方案。
Fifty-eight patients with advanced or recurrent or metastatic NPC were treated CTX +VCR + MTX + DDP(CtiMP)and DDP + BLM + MTC + MTX(PBM)regimens,49 patients were evaluabefor response,In 23 treated by COMP regimen 3 cases reached CR and 9 PR with tlie response rate(CR,+PR)of 52.2%(12/23).In 26 treated by PBM regimen 1 case reached CR and 9 PR with the response rate(CR +PR)of 38.s%(10/26).There was no statistical difference between there two groups(P>0.05).Me-dian response duration fo responded patients was 25 months(range 5～56 months).Better response was ob- tained by COMP in lung metastasis(58.3%,7/12),better response was obtained by PBM in local recurrentNPC(42. 9%, 3/7),lowest response was obtained in liver metastasis.Thus we considered that COMP maybe chosen as a first line treatment for metastasis of NPC,and BPM may be chosen as a first line treatmentfor recurrent NPC.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1996年第3期214-215,共2页
Chinese Journal of Cancer
关键词
鼻咽癌
联合化疗
药物疗法
疗效
Nasopharyngeal carcinoma Combined chemotherapy
