摘要
Ｗｉｓｔａｒ大鼠皮下注射醋酸考的松诱发卡氏肺孢子虫肺炎，自第６～１２周，每周解剖病鼠２只观察，全部给药鼠均发病。肺部病变表现为：（１）肺印片查见卡氏肺孢子虫包囊和滋养体。（２）组织病理学改变：第６～８周ＨＥ染色切片呈间质性肺炎伴中度淋巴细胞浸润，肺泡内缺乏泡沫样渗出物，第９～１２周肺泡内出现泡沫样渗出物，ＰＡＳ染色该渗出物呈阳性反应，ＧＭＳ染色查见染成黑色的包囊。（３）停用醋酸考的松后４～６周，肺部炎症明显好转，提示大鼠卡氏肺孢子虫肺炎有自愈可能。电镜显示包囊、滋养体及受损肺泡上皮细胞的超微结构。
In order to induce PCP,Wistar rats were injected subcuteneously with cortisone acetate twice a week for 12 weeks. From the 6th to 1 2th week,two rats were necropsied weekly. A development of PCP was found in experimental rats,Pathological changes showed:(1) the PC cysts and trophozoites were identified in impression smears,(2)histopathologic changes in HE staining sections were: from the 6th to 8th week,interstitial pneumonitis with moderate infiltration of lymphocytes and the absence of foamy intra-alveolar exudate; from the 9th to 12th week, the identification of foamy intra-alveolar exudate.With PAS staining, the exudate showed positive reaction. Black cysts were found in GMS staining sections. (3) After 4～6weeks of stopping injection with cortisone acetate,the PCP mended. It showed that the suffered rats may cure without any treatments. Electronic microscopy showed ultrastructure of PC cysts and trophozoites and injured alveolar epithelial cells.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1996年第2期148-150,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
肺炎
卡氏肺孢子肺炎
病理学
pneumocystis carinii pneumonia
immunosuppression
pathology
