摘要
目的：研究尼莫地平对感染性水肿的影响．方法：采用百日咳菌液右侧颈内动脉注射造成兔感染性脑水肿模型．１８只家兔随机分为３组（ｎ＝６）．ＢＥ组：注射百日咳菌液（０６ｍＬ·ｋｇ－１）；ＮＳ组：注射生理盐水作为对照．Ｎｉｍ组：注射菌液后１０ｍｉｎ，静注尼莫地平１０μｇ·ｋｇ－１，再以０７５μｇ·ｋｇ－１·ｍｉｎ－１持续静滴，４ｈ后观察右脑伊文斯蓝蓝染，测定右脑水、钙、钙调素及钠含量．结果：Ｎｉｍ与ＢＥ：水８２２±１０％和８４４±１２（Ｐ＜００１）；钙１０５±１３ｍｍｏｌ／ｋｇ干脑和１７５±１４（Ｐ＜００１）；钙调素１５９±１８μｍｏｌ／ｋｇ湿脑和２４０±３０（Ｐ＜０．０１）；钠１７３±７ｍｍｏｌ／ｋｇ干脑和２７５±３８（Ｐ＜００５）．两组脑蓝染无显著性差异．结论：尼莫地平对感染性脑水肿有良好的治疗作用．
AIM: To study
the effect of nimodipine (Nim) on infectious brain edema (BE).
METHODS: An infectious BE model was induced by injection of
Bordetella pertussis suspension (BPS) into right internal carotid
artery in rabbits. Eighteen rabbits were randomly divided into 3
groups ( n =6). Group BE: BPS (0 6 mL·kg -1 ) was given;
group NS: normal saline was given as control; group Nim: 10 min after
injection of BPS, Nim, 10 μg ·kg -1 , was injected iv as a
bolus followed by continuous infusion of 0 75 μg·kg -1 ·min
-1 . All the rabbits were kept under observation for 4 h. Evans blue
staining was assessed; water, calcium, calmodulin (Cal), and sodium
contents were determined in the right brain. RESULTS: Nim vs BE:
water 82 2±1 0 % vs 84 4±1 2 ( P <0 01); calcium 10 5±1
3 mmol·kg -1 dry tissue vs 17 5±1 4 ( P <0 01); Cal
15 9±1 8 μmol·kg -1 wet tissue vs 24 0±3 0 ( P <0
01); sodium 173±7 mmol·kg -1 dry tissue vs 275±38 ( P
<0 05). No significant difference for Evans blue staining between
the two groups. CONCLUSION: Nim had beneficial effect on the
infectious BE.
出处
《中国药理学报》
CSCD
1996年第3期213-214,共2页
Acta Pharmacologica Sinica
关键词
百日咳杆菌
脑水肿
尼莫地平
钙调素
伊文思蓝
Bordetella pertussis
brain edema
nimodipine
water
calcium
calmodulin
sodium
Evans blue
