摘要
目的研究乳腺癌皮肤和乳头的受累概率,分析术式改良的可行性。方法对90例乳腺癌患者,术后皮肤在距肿瘤最近点取材,乳头乳晕复合体经正中切面取材做病理检查,了解皮肤及乳头乳晕复合体受累情况。结果90例乳腺癌中,3例皮肤及乳头乳晕复合体见癌浸润,肿块均位于中心区且肿块位置表浅,其中2例有乳头内陷,2例有桔皮征,1例肿瘤表面皮肤呈紫红色,1例为Paget病。另外有2例皮肤破溃,皮肤受累。结论皮肤及乳头乳晕复合体受累与肿瘤类型、肿瘤位置、局部皮肤改变、乳头改变及与皮肤或乳头粘连有关。如果无皮肤及乳头乳晕复合体受累临床征象,可以行保留皮肤和保留乳头的乳房切除术或利用腔镜技术进行乳腺癌外科治疗。
Objective To investigate the incidence of nipple-skin invasion （NSI） in breast cancer and evaluate the feasibility of operation improvement. Methods Samples of both visually normal skin nearest to the tumor and midline-transection of nipple-areola complex （NAC） collected from the excised mammary glands of ninety randomized patients with breast cancer were sent to pathological examinations to evaluate the severity of NSI. Results NSI was morphologically demonstrated in five cases, among whom 3 patients had NAC involvement with nipple retraction in 2 cases, orange peel appearance in 2 cases, purplish red alteration of local skin in 1 case and Paget＇s disease in 1 case. The tumors were all located superficially and centrally to the breast. The other two patients had cancerous ulceration on the local skin, but NAC was amnestied. Conclusion Many factors are interrelated with the incidence of NSI, such as： pathological type of the tumor, tumor position, alteration of local skin or nipple, or whether adherence to the skin or nipple occurs. If no clinical sign of NSI is found, tumor ablation through skin-sparing mastectomy, nipple-sparing mastectomy or minimally invasive techniques is suggested.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2005年第5期430-432,共3页
Journal of Harbin Medical University
