摘要
目的:观察盐酸丁咯地尔注射液治疗糖尿病周围神经病变的疗效及安全性。方法:将48例住院患者随机分为两组,两组均常规行降糖药物治疗,试验组(n=25)加用盐酸丁咯地尔注射液200 mg加入生理氯化钠溶液250 mL中静滴,qd,对照组(n=23)用复方丹参注射液16 mL加入生理氯化钠溶液250 mL中静滴,qd。两组均14 d为1个疗程,间隔2 d再用1个疗程,总疗程30 d。评价两组治疗前后有效率以及感觉神经传导速度(SCV)。结果:试验组总有效率为88.0%,明显高于对照组60.8%,两组比较差异有显著性(P<0.05),与对照组比较,试验组正中神经、尺神经、腓总神经和胫神经的SCV均有提高(P<0.05),主要的不良反应为上腹部不适、头晕、嗜睡等,对症处理后症状消失。结论:盐酸丁咯地尔注射液治疗糖尿病周围神经病变疗效满意。
Objective：To evaluate the efficacy and safety of buflomedil hydrochloride for injection in the treatment of diabetic peripheral neuropathy. Methods ： 48 inhospitalized patients with diabetic peripheral neuropathy were randomly assigned to one of treatment groups; the treatment group（ n = 25） received adjuvant therapy of conventional glucose-controlled drug with buflomedil hydrochloride for injection （200 mg）, the control group（ n = 23） administered the combination of conventional glucose-controlled drug with a compound Salvia miltiorrhiza for injection （total 16 mL）. Both groups were infused once daily for 14 days. The therapeutic regimens were repeated for additional 14 days in a 2-day interval after the first cycle of the 14-day therapy. The efficacy of the therapy was assessed based on the SCV（sensery nerves conduction velocity） status prior to and post therapy. Results： The total efficacy rate of the treatment and control group showed a significant difference （88.0% vs. 60.8%, P 〈 0.05） . Compared to the control group, the patients in the treatment group experienced significant improvements of the SCV （ P 〈 0.05 ）. The common adverse events in the treatment of buflomedil hydrochloride for injection were abdominal disorder, dizzy and somnolence.Conclusion： Buflomedil hydrochloride for injection showed an adjuvant therapeutic benefit in the treatment of diabetic peripheral neuropathy.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2005年第10期1218-1220,共3页
Chinese Journal of New Drugs
关键词
盐酸丁咯地尔
糖尿病
周围神经病变
感觉神经传导速度
buflomedil hydrochloride for injection
diabetic
peripheral nenropathy
sdnsery nerves conduction velocity
